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return kwic search for provide out of >500 occurrences
325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [no cache] 500 found

302) These results suggest that inhibition of β-arrestin 2 in the brain with specific agRNAs can improve morphine efficacy, and consequently provide us a useful strategy for treatment of chronic intractable pain and morphine tolerance in vivo.

--- ABSTRACT ---

PMID:24555516 DOI:10.3109/00207454.2014.896913

2015 The International journal of neuroscience

* Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of β-arrestin 2 with antigene RNAs in mice.

- β-arrestin 2, a regulatory molecule of G protein-coupled receptor, has been proved to play an important role in regulating functions of mu opioid receptor. Changes of β-arrestin 2 expression might affect the function of mu opioid receptors and the effect of its agonists. In this study, antigene RNAs (agRNAs), which could selectively target gene transcription start sites and potently inhibit gene expression, were used to downregulate the expression of β-arrestin 2 to investigate its effects on morphine analgesia and tolerance in mice. After intracerebroventricular administration of recombinant lentivirus encoding β-arrestin 2 agRNAs to the mice, β-arrestin 2 expression was significantly decreased for more than 3 weeks. Mice treated with β-arrestin 2 agRNAs showed enhanced analgesic effects in response to morphine and failed to develop antinociceptive tolerance. These results suggest that inhibition of β-arrestin 2 in the brain with specific agRNAs can improve morphine efficacy, and consequently provide us a useful strategy for treatment of chronic intractable pain and morphine tolerance in vivo.

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[frequency of next (right) word to provide]

(1)109 a	(12)6 insight	(23)3 care	(34)2 effective
(2)39 an	(13)6 recommendations	(24)3 direct	(35)2 first
(3)32 the	(14)5 reliable	(25)3 guidance	(36)2 for
(4)25 evidence	(15)5 them	(26)3 novel	(37)2 good
(5)14 useful	(16)4 information	(27)3 preliminary	(38)2 greater
(6)13 new	(17)4 insights	(28)2 accurate	(39)2 methodological
(7)8 more	(18)4 such	(29)2 additional	(40)2 one
(8)7 rather	(19)4 us	(30)2 analytical	(41)2 some
(9)7 support	(20)4 valuable	(31)2 answers	(42)2 sufficient
(10)6 further	(21)3 adequate	(32)2 basic	(43)2 to
(11)6 important	(22)3 better	(33)2 clinically

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--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---