ELIZA

return kwic search for provide out of >500 occurrences
325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]

221) Taken together, these data demonstrate that RECK contributes to GA's anti-invasive activity and provide new evidence for GA being served as a therapeutic candidate for cancer metastasis.

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PMID:24532189 DOI:10.1002/mc.22138

2015 Molecular carcinogenesis

* Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells.

- Gambogic acid (GA), a xanthone derived from the resin of the Garcinia hanburyi, has been demonstrated possessing anti-metastatic activity in vitro and in vivo. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein negatively regulating matrix metalloproteinases (MMPs), plays an important role in tumor invasion and metastasis. The present study investigates the regulatory effect of GA on RECK expression and the role of RECK in GA-induced anti-invasion in A549 human lung cancer cells. Our results showed that GA dose-dependently inhibited cell invasion and suppressed A549 experimental lung metastasis in vivo, which was attributed to RECK up-regulation at both protein and mRNA levels. With small interference RNA (siRNA) blocking RECK expression, we found inhibition of RECK decreased the GA-induced inhibition of MMP-2/9, which was in consistent with the attenuated anti-invasive effect of GA. Further study indicated that GA effectively suppressed Histone deacetylase (HDAC) 1/specificity protein (Sp) 1 binding and Sp1 phosphorylation associating with Extracellular signal-regulated kinases (ERK) signaling blocking, leading to RECK up-regulation. Taken together, these data demonstrate that RECK contributes to GA's anti-invasive activity and provide new evidence for GA being served as a therapeutic candidate for cancer metastasis.

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[frequency of next (right) word to provide]

(1)109 a	(12)6 insight	(23)3 care	(34)2 effective
(2)39 an	(13)6 recommendations	(24)3 direct	(35)2 first
(3)32 the	(14)5 reliable	(25)3 guidance	(36)2 for
(4)25 evidence	(15)5 them	(26)3 novel	(37)2 good
(5)14 useful	(16)4 information	(27)3 preliminary	(38)2 greater
(6)13 new	(17)4 insights	(28)2 accurate	(39)2 methodological
(7)8 more	(18)4 such	(29)2 additional	(40)2 one
(8)7 rather	(19)4 us	(30)2 analytical	(41)2 some
(9)7 support	(20)4 valuable	(31)2 answers	(42)2 sufficient
(10)6 further	(21)3 adequate	(32)2 basic	(43)2 to
(11)6 important	(22)3 better	(33)2 clinically

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--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---