ELIZA

return kwic search for present out of >500 occurrences
505151 occurrences (No.26 in the rank) during 5 years in the PubMed. [cache]

254) Activating Ras mutations, present in about 20% of human cancers, compromise the GTPase activity of Ras and therefore trigger accumulation of Ras in the GTP-bound state.

--- ABSTRACT ---

PMID:24219000 DOI:10.1089/hum.2013.171

2015 Current clinical pharmacology

* K-Ras, intestinal homeostasis and colon cancer.

- Activating Ras mutations, present in about 20% of human cancers, compromise the GTPase activity of Ras and therefore trigger accumulation of Ras in the GTP-bound state. Among the three family members, K-Ras, H-Ras and N-Ras, K-Ras is the most frequently mutated gene, with 30-50% of colon cancer patients harboring activating K-Ras mutations. Oncogenic mutations of K-Ras have been found at codons 12, 13, 61 and 146. Activation of Ras triggers constitutive activation of signaling pathways, including the MAPK and AKT pathways, which allows tumor cells to proliferate in the absence of growth factors and increases their survival. In addition, activated Ras triggers inflammation and thus promotes tumor progression in a cell non-autonomous manner. The presence of K-Ras mutations not only has prognostic value, but it also predicts the responsiveness of colon cancer patients to inhibitors of EGFR signaling.

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[frequency of next (right) word to present]

(1)151 study	(10)8 review	(19)3 findings	(28)2 only
(2)60 a	(11)7 investigation	(20)3 on	(29)2 paper,
(3)37 study,	(12)6 an	(21)3 our	(30)2 report,
(4)36 in	(13)6 case	(22)3 research	(31)2 studies
(5)21 the	(14)5 article	(23)2 as	(32)2 this
(6)10 results	(15)5 data	(24)2 between	(33)2 to
(7)9 null	(16)4 and	(25)2 case,	(34)2 work
(8)9 with	(17)4 here	(26)2 either
(9)8 at	(18)4 two	(27)2 more

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--- WordNet output for present --- =>出席している, そこにある, 現在の, 今の, 当面の, いあわせている, 考慮している, 現在, を人に贈る, 進呈する, を与える, を渡す, を紹介する, を公開する, を見せる, 示す, 贈り物, 【文法】現在時制の, プレゼント, 贈る, ある, 現在形の Overview of noun present The noun present has 3 senses (first 2 from tagged texts) 1. (17) present, nowadays -- (the period of time that is happening now; any continuous stretch of time including the moment of speech; "that is enough for the present"; "he lives in the present with no thought of tomorrow") 2. (4) present -- (something presented as a gift; "his tie was a present from his wife") 3. present, present tense -- (a verb tense that expresses actions or states at the time of speaking) Overview of verb present The verb present has 13 senses (first 10 from tagged texts) 1. (40) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (28) present, represent, lay out -- (bring forward and present to the mind; "We presented the arguments to him"; "We cannot represent this knowledge to our formal reason") 3. (14) stage, present, represent -- (perform (a play), especially on a stage; "we are going to stage `Othello'") 4. (13) present, submit -- (hand over formally) 5. (7) present, pose -- (introduce; "This poses an interesting question") 6. (3) award, present -- (give, especially as an honor or reward; "bestow honors and prizes at graduation") 7. (3) give, gift, present -- (give as a present; make a gift of; "What will you give her for her birthday?") 8. (3) deliver, present -- (deliver (a speech, oration, or idea); "The commencement speaker presented a forceful speech that impressed the students") 9. (2) introduce, present, acquaint -- (cause to come to know personally; "permit me to acquaint you with my son"; "introduce the new neighbors to the community") 10. (1) portray, present -- (represent abstractly, for example in a painting, drawing, or sculpture; "The father is portrayed as a good-looking man in this painting") 11. confront, face, present -- (present somebody with something, usually to accuse or criticize; "We confronted him with the evidence"; "He was faced with all the evidence and could no longer deny his actions"; "An enormous dilemma faces us") 12. present -- (formally present a debutante, a representative of a country, etc.) 13. salute, present -- (recognize with a gesture prescribed by a military regulation; assume a prescribed position; "When the officers show up, the soldiers have to salute") Overview of adj present The adj present has 2 senses (first 2 from tagged texts) 1. (60) present -- (temporal sense; intermediate between past and future; now existing or happening or in consideration; "the present leader"; "articles for present use"; "the present topic"; "the present system"; "present observations") 2. (39) present -- (being or existing in a specified place; "the murderer is present in this room"; "present at the wedding"; "present at the creation") --- WordNet end ---