ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for present out of >500 occurrences
505151 occurrences (No.26 in the rank) during 5 years in the PubMed. [cache]
244) In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo.
--- ABSTRACT ---
PMID:24038534 DOI:10.1002/mc.22080
2015 Molecular carcinogenesis
* Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.
- STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo. BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates. There was a concomitant increase in the Lgr-6, Lrig-1, and Sca-1 populations in the Tg mice in contrast to the CD34 and Keratin-15 positive population. In addition, increased expression of c-myc, β-catenin, and epithelial-mesenchymal transition (EMT)-related genes as well as decreased expression of α6-integrin was observed in the hair follicles of Tg mice. Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes. The current data suggest that elevated Stat3 activity leads to depletion of hair follicle KSCs along with a concomitant increase of stem/progenitor cells above the bulge region. Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.
--- ABSTRACT END ---
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[frequency of next (right) word to present]
(1)151 study (10)8 review (19)3 findings (28)2 only
(2)60 a (11)7 investigation (20)3 on (29)2 paper,
(3)37 study, (12)6 an (21)3 our (30)2 report,
(4)36 in (13)6 case (22)3 research (31)2 studies
(5)21 the (14)5 article (23)2 as (32)2 this
(6)10 results (15)5 data (24)2 between (33)2 to
(7)9 *null* (16)4 and (25)2 case, (34)2 work
(8)9 with (17)4 here (26)2 either
(9)8 at (18)4 two (27)2 more

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--- WordNet output for present --- =>出席している, そこにある, 現在の, 今の, 当面の, いあわせている, 考慮している, 現在, を人に贈る, 進呈する, を与える, を渡す, を紹介する, を公開する, を見せる, 示す, 贈り物, 【文法】現在時制の, プレゼント, 贈る, ある, 現在形の Overview of noun present The noun present has 3 senses (first 2 from tagged texts) 1. (17) present, nowadays -- (the period of time that is happening now; any continuous stretch of time including the moment of speech; "that is enough for the present"; "he lives in the present with no thought of tomorrow") 2. (4) present -- (something presented as a gift; "his tie was a present from his wife") 3. present, present tense -- (a verb tense that expresses actions or states at the time of speaking) Overview of verb present The verb present has 13 senses (first 10 from tagged texts) 1. (40) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (28) present, represent, lay out -- (bring forward and present to the mind; "We presented the arguments to him"; "We cannot represent this knowledge to our formal reason") 3. (14) stage, present, represent -- (perform (a play), especially on a stage; "we are going to stage `Othello'") 4. (13) present, submit -- (hand over formally) 5. (7) present, pose -- (introduce; "This poses an interesting question") 6. (3) award, present -- (give, especially as an honor or reward; "bestow honors and prizes at graduation") 7. (3) give, gift, present -- (give as a present; make a gift of; "What will you give her for her birthday?") 8. (3) deliver, present -- (deliver (a speech, oration, or idea); "The commencement speaker presented a forceful speech that impressed the students") 9. (2) introduce, present, acquaint -- (cause to come to know personally; "permit me to acquaint you with my son"; "introduce the new neighbors to the community") 10. (1) portray, present -- (represent abstractly, for example in a painting, drawing, or sculpture; "The father is portrayed as a good-looking man in this painting") 11. confront, face, present -- (present somebody with something, usually to accuse or criticize; "We confronted him with the evidence"; "He was faced with all the evidence and could no longer deny his actions"; "An enormous dilemma faces us") 12. present -- (formally present a debutante, a representative of a country, etc.) 13. salute, present -- (recognize with a gesture prescribed by a military regulation; assume a prescribed position; "When the officers show up, the soldiers have to salute") Overview of adj present The adj present has 2 senses (first 2 from tagged texts) 1. (60) present -- (temporal sense; intermediate between past and future; now existing or happening or in consideration; "the present leader"; "articles for present use"; "the present topic"; "the present system"; "present observations") 2. (39) present -- (being or existing in a specified place; "the murderer is present in this room"; "present at the wedding"; "present at the creation") --- WordNet end ---