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kwic search for present out of >500 occurrences
505151 occurrences (No.26 in the rank) during 5 years in the PubMed. [no cache]
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238) In the present study, we evaluated TP53 mutations in NSCLCs by direct sequencing and observed remarkable variation in the values of relative intensity (RI, the height of the peak of mutated allele/the height of the peak of non-mutated allele) of the mutations.
* The influence of TP53 mutations on the prognosis of patients with early stage non-small cell lung cancer may depend on the intratumor heterogeneity of the mutations.
- A large number of studies have evaluated the impact of TP53 mutations on the prognosis of patients with non-small cell lung cancer (NSCLC); however, the results of these studies are still controversial. Recently, considerable intratumor heterogeneity for genetic alterations has been demonstrated in various human cancers, including lung cancer. In the present study, we evaluated TP53 mutations in NSCLCs by direct sequencing and observed remarkable variation in the values of relative intensity (RI, the height of the peak of mutated allele/the height of the peak of non-mutated allele) of the mutations. We also examined whether the RI values were associated with intratumor heterogeneity of TP53 mutations. In addition, we evaluated the relationship between TP53 mutations and survival outcome. The patients with a TP53 mutation did not have significantly worse survival compared to those without the mutation. However, when tumors with a TP53 mutation were categorized into two groups, those with a low and those with a high RI, the latter group had significantly worse survival compared to those with wild-type TP53 (adjusted hazard ratio = 2.58, 95% confidence interval = 1.21-5.48, P = 0.01), whereas the former group did not. These results suggest that intratumor genetic heterogeneity may be an important factor in determining the role of TP53 mutations on the prognosis of NSCLC patients.
=>出席している, そこにある, 現在の, 今の, 当面の, いあわせている, 考慮している, 現在, を人に贈る,
進呈する, を与える, を渡す, を紹介する, を公開する, を見せる, 示す, 贈り物, 【文法】現在時制の,
プレゼント, 贈る, ある, 現在形の
Overview of noun present
The noun present has 3 senses (first 2 from tagged texts)
1. (17) present, nowadays -- (the period of time that is happening now; any continuous stretch of
time including the moment of speech; "that is enough for the present"; "he lives in the present with
no thought of tomorrow")
2. (4) present -- (something presented as a gift; "his tie was a present from his wife")
3. present, present tense -- (a verb tense that expresses actions or states at the time of speaking)
Overview of verb present
The verb present has 13 senses (first 10 from tagged texts)
1. (40) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested
audience; "She shows her dogs frequently"; "We will demo the new software in Washington")
2. (28) present, represent, lay out -- (bring forward and present to the mind; "We presented the
arguments to him"; "We cannot represent this knowledge to our formal reason")
3. (14) stage, present, represent -- (perform (a play), especially on a stage; "we are going to
stage `Othello'")
4. (13) present, submit -- (hand over formally)
5. (7) present, pose -- (introduce; "This poses an interesting question")
6. (3) award, present -- (give, especially as an honor or reward; "bestow honors and prizes at
graduation")
7. (3) give, gift, present -- (give as a present; make a gift of; "What will you give her for her
birthday?")
8. (3) deliver, present -- (deliver (a speech, oration, or idea); "The commencement speaker
presented a forceful speech that impressed the students")
9. (2) introduce, present, acquaint -- (cause to come to know personally; "permit me to acquaint you
with my son"; "introduce the new neighbors to the community")
10. (1) portray, present -- (represent abstractly, for example in a painting, drawing, or sculpture;
"The father is portrayed as a good-looking man in this painting")
11. confront, face, present -- (present somebody with something, usually to accuse or criticize; "We
confronted him with the evidence"; "He was faced with all the evidence and could no longer deny his
actions"; "An enormous dilemma faces us")
12. present -- (formally present a debutante, a representative of a country, etc.)
13. salute, present -- (recognize with a gesture prescribed by a military regulation; assume a
prescribed position; "When the officers show up, the soldiers have to salute")
Overview of adj present
The adj present has 2 senses (first 2 from tagged texts)
1. (60) present -- (temporal sense; intermediate between past and future; now existing or happening
or in consideration; "the present leader"; "articles for present use"; "the present topic"; "the
present system"; "present observations")
2. (39) present -- (being or existing in a specified place; "the murderer is present in this room";
"present at the wedding"; "present at the creation")
--- WordNet end ---