* The crude extract of Corni Fructus inhibits the migration and invasion of U-2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
- Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U-2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U-2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF-κB p65, COX-2, HIF-1α, PI3K, Rho A, ROCK-1, IRE-1α, p-JNK1/2, p-ERK1/2, p-p38, Ras, p-PERK, MMP-2, MMP-9, and VEGF in U-2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells.
=>出席している, そこにある, 現在の, 今の, 当面の, いあわせている, 考慮している, 現在, を人に贈る,
進呈する, を与える, を渡す, を紹介する, を公開する, を見せる, 示す, 贈り物, 【文法】現在時制の,
プレゼント, 贈る, ある, 現在形の
Overview of noun present
The noun present has 3 senses (first 2 from tagged texts)
1. (17) present, nowadays -- (the period of time that is happening now; any continuous stretch of
time including the moment of speech; "that is enough for the present"; "he lives in the present with
no thought of tomorrow")
2. (4) present -- (something presented as a gift; "his tie was a present from his wife")
3. present, present tense -- (a verb tense that expresses actions or states at the time of speaking)
Overview of verb present
The verb present has 13 senses (first 10 from tagged texts)
1. (40) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested
audience; "She shows her dogs frequently"; "We will demo the new software in Washington")
2. (28) present, represent, lay out -- (bring forward and present to the mind; "We presented the
arguments to him"; "We cannot represent this knowledge to our formal reason")
3. (14) stage, present, represent -- (perform (a play), especially on a stage; "we are going to
stage `Othello'")
4. (13) present, submit -- (hand over formally)
5. (7) present, pose -- (introduce; "This poses an interesting question")
6. (3) award, present -- (give, especially as an honor or reward; "bestow honors and prizes at
graduation")
7. (3) give, gift, present -- (give as a present; make a gift of; "What will you give her for her
birthday?")
8. (3) deliver, present -- (deliver (a speech, oration, or idea); "The commencement speaker
presented a forceful speech that impressed the students")
9. (2) introduce, present, acquaint -- (cause to come to know personally; "permit me to acquaint you
with my son"; "introduce the new neighbors to the community")
10. (1) portray, present -- (represent abstractly, for example in a painting, drawing, or sculpture;
"The father is portrayed as a good-looking man in this painting")
11. confront, face, present -- (present somebody with something, usually to accuse or criticize; "We
confronted him with the evidence"; "He was faced with all the evidence and could no longer deny his
actions"; "An enormous dilemma faces us")
12. present -- (formally present a debutante, a representative of a country, etc.)
13. salute, present -- (recognize with a gesture prescribed by a military regulation; assume a
prescribed position; "When the officers show up, the soldiers have to salute")
Overview of adj present
The adj present has 2 senses (first 2 from tagged texts)
1. (60) present -- (temporal sense; intermediate between past and future; now existing or happening
or in consideration; "the present leader"; "articles for present use"; "the present topic"; "the
present system"; "present observations")
2. (39) present -- (being or existing in a specified place; "the murderer is present in this room";
"present at the wedding"; "present at the creation")
--- WordNet end ---