kwic
potential
potential
right
off
ON
76
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to potential]
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 76) We therefore propose that genetic variation in ST8SIA2 has the potential to confer a neurodevelopmental predisposition to schizophrenia. |
| PMID:24057454 DOI:10.1007/s00429-013-0638-z |
| 2015 Brain structure & function |
| * Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. |
| - Posttranslational modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is crucial for nervous system development and brain plasticity. PolySia attachment is catalyzed by the polysialyltransferases (polySTs) ST8SIA2 and ST8SIA4, two enzymes with distinct but also common functions during neurodevelopment and in the adult brain. A growing body of evidence links aberrant levels of NCAM and polySia as well as variation in the ST8SIA2 gene to neuropsychiatric disorders, including schizophrenia. To investigate whether polyST deficiency might cause a schizophrenia-like phenotype, St8sia2 (-/-) mice, St8sia4 (-/-) mice and their wildtype littermates were assessed neuroanatomically and subjected to tests of cognition and sensorimotor functions. St8sia2 (-/-) but not St8sia4 (-/-) mice displayed enlarged lateral ventricles and a size reduction of the thalamus accompanied by a smaller internal capsule and a highly disorganized pattern of fibers connecting thalamus and cortex. Reduced levels of the vesicular glutamate transporter VGLUT2 pointed towards compromised glutamatergic thalamocortical input into the frontal cortex of St8sia2 (-/-) mice. Both polyST-deficient lines were impaired in short- and long-term recognition memory, but only St8sia2 (-/-) mice displayed impaired working memory and deficits in prepulse inhibition. Furthermore, only the St8sia2 (-/-) mice exhibited anhedonic behavior and increased sensitivity to amphetamine-induced hyperlocomotion. These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior. We therefore propose that genetic variation in ST8SIA2 has the potential to confer a neurodevelopmental predisposition to schizophrenia. |
[
right
kwic]
(1)67  of |
(15)4 effects |
(29)2 by |
(43)2 mediator |
| (2)39 to |
(16)4 guardian |
(30)2 clinical |
(44)2 new |
| (3)35 for |
(17)4 mechanism |
(31)2 confounders |
(45)2 pathways |
| (4)14 *null* | (18)4 mechanisms |
(32)2 confounders, |
(46)2 perils |
| (5)13 in |
(19)3 adverse |
(33)2 directions |
(47)2 preventive |
| (6)10 as |
(20)3 applications |
(34)2 drug |
(48)2 risks |
| (7)10 risk |
(21)3 association |
(35)2 factors |
(49)2 than |
| (8)8 role |
(22)3 cytotoxicity |
(36)2 future |
(50)2 therapy |
| (9)8 use |
(23)3 genotoxic |
(37)2 harm |
(51)2 toxicity |
| (10)7 and |
(24)3 influence |
(38)2 hazards |
(52)2 vaccine |
| (11)7 therapeutic |
(25)3 pitfalls |
(39)2 impact |
(53)2 was |
| (12)6 benefits |
(26)3 utility |
(40)2 is |
|
| (13)5 health |
(27)3 value |
(41)2 issues |
|
| (14)5 predictors |
(28)2 biomarker |
(42)2 maximum |
add keyword
--- WordNet output for potential ---