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return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found

68) This electromagnetic field increased osteogenic gene expression, alkaline phosphate activity and nodule formation in vitro within 2 weeks, indicating that this pretreatment may provide osteogenic potential to ASCs on three-dimensional (3D) ceramic scaffolds.

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PMID:23281198 DOI:10.1002/term.1664

2015 Journal of tissue engineering and regenerative medicine

* Short-term evaluation of electromagnetic field pretreatment of adipose-derived stem cells to improve bone healing.

- An electromagnetic field is an effective stimulation tool because it promotes bone defect healing, albeit in an unknown way. Although electromagnetic fields are used for treatment after surgery, many patients prefer cell-based tissue regeneration procedures that do not require daily treatments. This study addressed the effects of an electromagnetic field on adipose-derived stem cells (ASCs) to investigate the feasibility of pretreatment to accelerate bone regeneration. After identifying a uniform electromagnetic field inside a solenoid coil, we observed that a 45 Hz electromagnetic field induced osteogenic marker expression via bone morphogenetic protein, transforming growth factor β, and Wnt signalling pathways based on microarray analyses. This electromagnetic field increased osteogenic gene expression, alkaline phosphate activity and nodule formation in vitro within 2 weeks, indicating that this pretreatment may provide osteogenic potential to ASCs on three-dimensional (3D) ceramic scaffolds. This pretreatment effect of an electromagnetic field resulted in significantly better bone regeneration in a mouse calvarial defect model over 4 weeks compared to that in the untreated group. This short-term evaluation showed that the electromagnetic field pretreatment may be a future therapeutic option for bone defect treatment.

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(1)67 of	(15)4 effects	(29)2 by	(43)2 mediator
(2)39 to	(16)4 guardian	(30)2 clinical	(44)2 new
(3)35 for	(17)4 mechanism	(31)2 confounders	(45)2 pathways
(4)14 null	(18)4 mechanisms	(32)2 confounders,	(46)2 perils
(5)13 in	(19)3 adverse	(33)2 directions	(47)2 preventive
(6)10 as	(20)3 applications	(34)2 drug	(48)2 risks
(7)10 risk	(21)3 association	(35)2 factors	(49)2 than
(8)8 role	(22)3 cytotoxicity	(36)2 future	(50)2 therapy
(9)8 use	(23)3 genotoxic	(37)2 harm	(51)2 toxicity
(10)7 and	(24)3 influence	(38)2 hazards	(52)2 vaccine
(11)7 therapeutic	(25)3 pitfalls	(39)2 impact	(53)2 was
(12)6 benefits	(26)3 utility	(40)2 is
(13)5 health	(27)3 value	(41)2 issues
(14)5 predictors	(28)2 biomarker	(42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---