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return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found

324) This study investigating the effects of silver nanoparticles in human lung epithelial cells has provided valuable insights into the mechanism of potential toxicity induced by silver nanoparticles and warrants more careful assessment of silver nanoparticles before their industrial applications.

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PMID:23804405 DOI:10.1002/tox.21880

2015 Environmental toxicology

* Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells.

- Silver nanoparticles are increasingly used in various products, due to their antibacterial properties. Despite its wide spread use, only little information on possible adverse health effects exists. Therefore, the aim of this study was to assess the toxic potential of silver nanoparticles (<100 nm) in human lung epithelial (A549) cells and the underlying mechanism of its cellular toxicity. Silver nanoparticles induced dose and time-dependent cytotoxicity in A549 cells demonstrated by MTT and LDH assays. Silver nanoparticles were also found to induce oxidative stress in dose and time-dependent manner indicated by depletion of GSH and induction of ROS, LPO, SOD, and catalase. Further, the activities of caspases and the level of proinflammatory cytokines, namely interleukin-1β (IL-1β) and interleukin-6 (IL-6) were significantly higher in treated cells. DNA damage, as measured by single cell gel electrophoresis, was also dose and time-dependent signicants in A549 cells. This study investigating the effects of silver nanoparticles in human lung epithelial cells has provided valuable insights into the mechanism of potential toxicity induced by silver nanoparticles and warrants more careful assessment of silver nanoparticles before their industrial applications.

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[frequency of next (right) word to potential]

(1)67 of	(15)4 effects	(29)2 by	(43)2 mediator
(2)39 to	(16)4 guardian	(30)2 clinical	(44)2 new
(3)35 for	(17)4 mechanism	(31)2 confounders	(45)2 pathways
(4)14 null	(18)4 mechanisms	(32)2 confounders,	(46)2 perils
(5)13 in	(19)3 adverse	(33)2 directions	(47)2 preventive
(6)10 as	(20)3 applications	(34)2 drug	(48)2 risks
(7)10 risk	(21)3 association	(35)2 factors	(49)2 than
(8)8 role	(22)3 cytotoxicity	(36)2 future	(50)2 therapy
(9)8 use	(23)3 genotoxic	(37)2 harm	(51)2 toxicity
(10)7 and	(24)3 influence	(38)2 hazards	(52)2 vaccine
(11)7 therapeutic	(25)3 pitfalls	(39)2 impact	(53)2 was
(12)6 benefits	(26)3 utility	(40)2 is
(13)5 health	(27)3 value	(41)2 issues
(14)5 predictors	(28)2 biomarker	(42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---