249) Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. |
PMID:24041870 DOI:10.1016/j.canlet.2013.09.009 |
2015 Cancer letters |
* Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects. |
- Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes. |
(1)67 of | (15)4 effects | (29)2 by | (43)2 mediator |
(2)39 to | (16)4 guardian | (30)2 clinical | (44)2 new |
(3)35 for | (17)4 mechanism | (31)2 confounders | (45)2 pathways |
(4)14 *null* | (18)4 mechanisms | (32)2 confounders, | (46)2 perils |
(5)13 in | (19)3 adverse | (33)2 directions | (47)2 preventive |
(6)10 as | (20)3 applications | (34)2 drug | (48)2 risks |
(7)10 risk | (21)3 association | (35)2 factors | (49)2 than |
(8)8 role | (22)3 cytotoxicity | (36)2 future | (50)2 therapy |
(9)8 use | (23)3 genotoxic | (37)2 harm | (51)2 toxicity |
(10)7 and | (24)3 influence | (38)2 hazards | (52)2 vaccine |
(11)7 therapeutic | (25)3 pitfalls | (39)2 impact | (53)2 was |
(12)6 benefits | (26)3 utility | (40)2 is | |
(13)5 health | (27)3 value | (41)2 issues | |
(14)5 predictors | (28)2 biomarker | (42)2 maximum |
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