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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache]
500 found
157) While clinical trials were able to demonstrate the efficacy of MSCs in cases of inflammatory bowel disease and degenerative conditions of the liver, controversial results have been presented regarding their antineoplastic potential in gastrointestinal tumours.
* [Significance of Mesenchymal Stem Cells in Gastrointestinal Disorders].
- In this review we summarise the recent developments regarding the experimental and clinical use of mesenchymal stem cells (MSCs), focusing mainly on the treatment of gastrointestinal disorders. Next to their relevance in the field of regenerative medicine and immunology, this population of cells has also raised great expectations for possible applications in cancer therapy. While clinical trials were able to demonstrate the efficacy of MSCs in cases of inflammatory bowel disease and degenerative conditions of the liver, controversial results have been presented regarding their antineoplastic potential in gastrointestinal tumours. MSCs can differentiate into a large variety of specialised cells. They are capable of regulating both wound healing and immune responses through paracrine and endocrine signalling. Moreover, MSCs can be transfected with a great number of different therapeutic genes - considering their ability to selectively migrate towards neoplastic tissues, this feature allows for targeted therapy of solid tumours. Transfected genes can be designed so that they are expressed exclusively in the vicinity of the tumour, eventually triggering apoptosis in cancer cells. In this review, we demonstrate the natural distribution of exogenously applied MSCs in the host. Furthermore, we mention various methods of tracking MSCs in vivo and different parameters of administration that tend to influence therapeutic outcome (e.g., origin of MSCs, mode of application, or the potency of transfected genes). Finally, this review points out the hazards of MSC therapy, emphasising the risks related to their widespread clinical use.
=>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位
Overview of noun potential
The noun potential has 2 senses (first 1 from tagged texts)
1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being)
2. electric potential, potential, potential difference, potential drop, voltage -- (the difference
in electrical charge between two points in a circuit expressed in volts)
Overview of adj potential
The adj potential has 2 senses (first 2 from tagged texts)
1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of
nuclear power")
2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients")
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