ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found
1) The optimized nanoparticles showed particle size of 218 nm, zeta potential of -25.4 mV, drug entrapment efficiency of 89% and release efficiency of 56% until 2 h.
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PMID:24219091 DOI:10.3109/10837450.2013.852576
2015 Pharmaceutical development and technology
* Feasibility of haloperidol-anchored albumin nanoparticles loaded with doxorubicin as dry powder inhaler for pulmonary delivery.
- Haloperidol (Hal) is a ligand that can target sigma 2 receptors over-expressed in non-small cell lung cancer. Hal targeted nanoparticles of bovine serum albumin (BSA) were prepared for pulmonary delivery of doxorubicin (DOX). The conjugation was confirmed by Fourier transform infrared spectroscopy (FTIR) and (1)H nuclear magnetic resonance ((1)H NMR) spectroscopic methods. Nanoparticles were prepared by desolvation method from BSA-Hal and were loaded with DOX. They were characterized for their morphology, particle size, zeta potential, drug loading and release efficiency. The optimized nanoparticles were spray-dried using trehalose, l-leucin and mannitol as dry powder inhaler (DPI) in different inlet temperatures between 80 and 120°C. The obtained nanocomposites were characterized for their aerodynamic diameter, specific surface area (cm(2)/g) and fine particle fraction (FPF) by a Cascade Impactor device. The optimized nanoparticles showed particle size of 218 nm, zeta potential of -25.4 mV, drug entrapment efficiency of 89% and release efficiency of 56% until 2 h. After spray drying of these nanoparticles, the best results were obtained from mannitol with an inlet temperature of 80°C which produced a mean aerodynamic diameter of 4.58 μm, FPF of 66% and specific surface area of 6302.99 cm(2)/g. The obtained results suggest that the designed DPI could be a suitable inhaler for targeted delivery of DOX in pulmonary delivery.
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[frequency of next (right) word to potential]
(1)67 of (15)4 effects (29)2 by (43)2 mediator
(2)39 to (16)4 guardian (30)2 clinical (44)2 new
(3)35 for (17)4 mechanism (31)2 confounders (45)2 pathways
(4)14 *null* (18)4 mechanisms (32)2 confounders, (46)2 perils
(5)13 in (19)3 adverse (33)2 directions (47)2 preventive
(6)10 as (20)3 applications (34)2 drug (48)2 risks
(7)10 risk (21)3 association (35)2 factors (49)2 than
(8)8 role (22)3 cytotoxicity (36)2 future (50)2 therapy
(9)8 use (23)3 genotoxic (37)2 harm (51)2 toxicity
(10)7 and (24)3 influence (38)2 hazards (52)2 vaccine
(11)7 therapeutic (25)3 pitfalls (39)2 impact (53)2 was
(12)6 benefits (26)3 utility (40)2 is
(13)5 health (27)3 value (41)2 issues
(14)5 predictors (28)2 biomarker (42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---