ELIZA

return kwic search for patients out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found

146) Indwelling foreign-body infections are a critical medical problem, especially in immunocompromised patients.

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PMID:23506400 DOI:10.1111/iwj.12061

2015 International wound journal

* Infection mechanism of biofilm-forming Staphylococcus aureus on indwelling foreign materials in mice.

- Indwelling foreign-body infections are a critical medical problem, especially in immunocompromised patients. To examine the pathogenicity of biofilm-forming bacteria settling on foreign materials, mice implanted with plastic discs were infected with Staphylococcus aureus. After opening a wide subcutaneous pocket on the dorsal side of mice with or without temporal leukocytopenia, a plastic sheet was placed in the left subcutaneous space; subsequently, bacteria in a planktonic state were dispersed over the subcutaneous space. Bacterial numbers were examined 7 days after inoculation. In subcutaneous tissue on the right, S. aureus was found only in leukocytopenic mice. Meanwhile, bacteria were detected on the plastic and neighbouring tissue in both leukocytopenic and normal mice; however, colony-forming analysis indicated that leukocytopenic mice possessed significantly more bacteria. Tissue reaction against bacteria was pathologically examined. Invading S. aureus induced severe inflammation. In transient leukocytopenic mice, bacterial microcolonies formed on the plastic as well as in the developed necrotic tissue - both of which were shielded from inflammatory cell infiltration - result in bacteraemia. These results indicate that biofilm-forming S. aureus settling on indwelling foreign material are tolerant against host immunity and assault neighbouring tissue, which may lead to chronic wound infection.

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[frequency of next (right) word to patients]

(1)129 with	(10)9 was	(19)4 using	(28)2 included
(2)48 null	(11)6 of	(20)3 admitted	(29)2 into
(3)42 were	(12)5 have	(21)3 experienced	(30)2 often
(4)37 and	(13)4 died	(22)3 on	(31)2 presented
(5)22 in	(14)4 from	(23)3 received	(32)2 receiving
(6)21 who	(15)4 is	(24)3 the	(33)2 this
(7)12 are	(16)4 to	(25)2 (6	(34)2 when
(8)10 undergoing	(17)4 treated	(26)2 after
(9)9 had	(18)4 underwent	(27)2 for

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---