ELIZA

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486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [no cache] 500 found

92) In this chapter we discuss the genetics, clinical presentation, and management of this condition, as well as new data from large-scale clinical research studies on the natural history of HD.

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PMID:23975844 DOI:10.1007/7854_2013_238

2015 Current topics in behavioral neurosciences

* Clinical Aspects of Huntington's Disease.

- Huntington's disease (HD) is a devastating inherited neurodegenerative condition characterized by progressive motor, cognitive, and psychiatric symptoms. Symptoms progress over 15-20 years, and there are currently no disease-modifying therapies. The causative genetic mutation is an expanded CAG repeat in the HTT gene encoding the Huntingtin protein, and is inherited in an autosomal dominant manner. In this chapter we discuss the genetics, clinical presentation, and management of this condition, as well as new data from large-scale clinical research studies on the natural history of HD.

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(1)19 Zealand	(19)4 targets	(37)2 Zealand,	(55)2 important
(2)13 bone	(20)3 DP	(38)2 avenues	(56)2 innovations
(3)12 approach	(21)3 York,	(39)2 biomarkers	(57)2 instrument
(4)11 and	(22)3 approaches	(40)2 blood	(58)2 methodologies
(5)10 method	(23)3 concepts	(41)2 case	(59)2 methods
(6)9 insights	(24)3 information	(42)2 cases	(60)2 parameters
(7)7 York	(25)3 insight	(43)2 challenges	(61)2 policy
(8)7 therapeutic	(26)3 light	(44)2 co-processed	(62)2 public
(9)5 data	(27)3 media	(45)2 compound	(63)2 risk
(10)5 molecular	(28)3 molecules	(46)2 concept	(64)2 strategies
(11)5 species	(29)3 regulation	(47)2 diagnostic	(65)2 strategy
(12)4 World	(30)3 research	(48)2 driver	(66)2 subspecies
(13)4 class	(31)3 technique	(49)2 drug	(67)2 training
(14)4 clinical	(32)3 treatment	(50)2 endemic	(68)2 type
(15)4 discoveries	(33)2 Graves'	(51)2 evidence	(69)2 way
(16)4 generation	(34)2 HIV	(52)2 findings
(17)4 measure	(35)2 South	(53)2 genetic
(18)4 model	(36)2 York/Japan	(54)2 health

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---