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486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [no cache] 500 found

240) Obtained results showed that this new strategy is very interesting and should be further explored for clinical applications.

--- ABSTRACT ---

PMID:24155167 DOI:10.1002/term.1812

2015 Journal of tissue engineering and regenerative medicine

* Conditioned medium as a strategy for human stem cells chondrogenic differentiation.

- Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting alternative for moving into the clinical application of these cells, as chondrocytes could be partially replaced by stem cells for this type of application. In the present study we aimed to achieve chondrogenic differentiation of two different sources of stem cells using conditioned medium, without adding growth factors. We tested both human bone marrow-derived mesenchymal stem cells (hBSMCs) and human Wharton's jelly-derived stem cells (hWJSCs). Conditioned medium obtained from a culture of human articular chondrocytes was used to feed the cells during the experiment. Cultures were performed in previously produced three-dimensional (3D) scaffolds, composed of a blend of 50:50 chitosan:poly(butylene succinate). Both types of stem cells were able to undergo chondrogenic differentiation without the addition of growth factors. Cultures using hWJSCs showed significantly higher GAGs accumulation and expression of cartilage-related genes (aggrecan, Sox9 and collagen type II) when compared to hBMSCs cultures. Conditioned medium obtained from articular chondrocytes induced the chondrogenic differentiation of MSCs and ECM formation. Obtained results showed that this new strategy is very interesting and should be further explored for clinical applications.

--- ABSTRACT END ---

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(1)19 Zealand	(19)4 targets	(37)2 Zealand,	(55)2 important
(2)13 bone	(20)3 DP	(38)2 avenues	(56)2 innovations
(3)12 approach	(21)3 York,	(39)2 biomarkers	(57)2 instrument
(4)11 and	(22)3 approaches	(40)2 blood	(58)2 methodologies
(5)10 method	(23)3 concepts	(41)2 case	(59)2 methods
(6)9 insights	(24)3 information	(42)2 cases	(60)2 parameters
(7)7 York	(25)3 insight	(43)2 challenges	(61)2 policy
(8)7 therapeutic	(26)3 light	(44)2 co-processed	(62)2 public
(9)5 data	(27)3 media	(45)2 compound	(63)2 risk
(10)5 molecular	(28)3 molecules	(46)2 concept	(64)2 strategies
(11)5 species	(29)3 regulation	(47)2 diagnostic	(65)2 strategy
(12)4 World	(30)3 research	(48)2 driver	(66)2 subspecies
(13)4 class	(31)3 technique	(49)2 drug	(67)2 training
(14)4 clinical	(32)3 treatment	(50)2 endemic	(68)2 type
(15)4 discoveries	(33)2 Graves'	(51)2 evidence	(69)2 way
(16)4 generation	(34)2 HIV	(52)2 findings
(17)4 measure	(35)2 South	(53)2 genetic
(18)4 model	(36)2 York/Japan	(54)2 health

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---