ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for model out of >500 occurrences
469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache] 500 found
366) We conclude that this animal model allows facile and rapid screening of biomaterials for bone regeneration in cortical femoral defects without requiring external fixation.
--- ABSTRACT ---
PMID:23225778 DOI:10.1002/term.1655
2015 Journal of tissue engineering and regenerative medicine
* A uni-cortical femoral defect model in the rat: evaluation using injectable hyaluronan hydrogel as a carrier for bone morphogenetic protein-2.
- The development of biomaterial for bone regeneration requires animal models that are reliable and designed to mimic clinically relevant situations. We have previously investigated hydrogels comprised of modified hyaluronic acid and polyvinyl alcohol in models of ectopic bone formation. This hydrogel induces bone regeneration when loaded with bone morphogenetic proteins (BMPs). To allow further optimization of hydrogels, we developed a new, femoral, non-critical-sized cortical defect model. In the rat femur, we drilled standardized, elongated unilateral cortical defects that did not require stabilization and that could be created bilaterally to allow paired comparisons of biomaterials. After optimizing the defect size, subsequent stress fractures occurred in only 8% and the defect healed partially over the 40 day study period. In a time-course experiment, we treated bone defects with the previously studied hyaluronan hydrogel loaded with 10 µg hydroxyapatite and 6 µg BMP-2. The shape of the defect allowed controlled containment of the material within the defect. The defect in the right leg was left untreated, while the left defect was filled with 40 µl of the BMP hydrogel. As determined by pQCT analysis, the treated defects had a higher bone mineral content, bone area and bone density than control defects. The relative difference was greatest between the groups at 10 and 20 days and diminished as the defect healed in the untreated legs. We conclude that this animal model allows facile and rapid screening of biomaterials for bone regeneration in cortical femoral defects without requiring external fixation.
--- ABSTRACT END ---
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(1)63 of (12)7 as (23)3 assessment (34)2 demonstrated
(2)55 *null* (13)6 are (24)3 fit (35)2 it
(3)35 for (14)6 system (25)3 revealed (36)2 joints
(4)28 was (15)5 a (26)3 showed (37)2 may
(5)26 to (16)5 selection (27)3 systems (38)2 not
(6)16 and (17)5 which (28)3 were (39)2 results
(7)16 in (18)5 will (29)2 allows (40)2 species
(8)16 is (19)4 can (30)2 analyses (41)2 such
(9)16 with (20)4 parameters (31)2 appropriate (42)2 used
(10)12 that (21)4 using (32)2 biological
(11)8 the (22)4 we (33)2 consists

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--- WordNet output for model --- =>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする, 手本となる Overview of noun model The noun model has 9 senses (first 7 from tagged texts) 1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems") 2. (11) model -- (a type of product; "his car was an old model") 3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president didn't have time to be a model so the artist worked from photos") 4. (4) model, simulation -- (representation of something (sometimes on a smaller scale)) 5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of success"; "a model of clarity"; "he is the very model of a modern major general") 6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model") 7. (1) model, example -- (a representative form or pattern; "I profited from his example") 8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to display fashions; "she was too fat to be a mannequin") 9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale)) Overview of verb model The verb model has 6 senses (first 2 from tagged texts) 1. (1) model, pattern -- (plan or create according to a model or models) 2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay") 3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman who posed for Leonardo so often") 4. model -- (display (clothes) as a mannequin; "model the latest fashion") 5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights") 6. model, mock up -- (construct a model of; "model an airplane") Overview of adj model The adj model has 1 sense (first 1 from tagged texts) 1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens") --- WordNet end ---