ELIZA

return kwic search for model out of >500 occurrences
469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache] 500 found

361) As proteinopathies are caused by the aggregation of disease-typical proteins with an ordered structure, active and passive immunization protocols have been used to expose model systems to therapeutic antibodies that bind to the aggregates thereby inhibiting the prolongation into higher ordered fibrils or dissolving the existing fibrillar structure.

--- ABSTRACT ---

PMID:23642796 DOI:10.1016/j.euroneuro.2013.03.007

2015 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

* Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?

- The current review covers proteinopathies an umbrella term for neurodegenerative disorders that are characterized by the accumulation of specific proteins within neurons or in the brain parenchyma. Most prevalent examples for typical proteinopathies are Alzheimer's disease and Parkinson's disease. In healthy brain, these proteins are unstructured as a monomer, serving most likely as the physiological form. In a disease condition, the unstructured proteins experience a conformational change leading to small oligomers that eventually will aggregate into higher order structures. Prion disease is an exception within the family of proteinopathies as the aggregated prion protein is highly infectious and can self-aggregate and propagate. Recent reports might implicate a prion-like spread of misfolded proteins in Alzheimer's and Parkinson's disease; however there are evident differences in comparison to prion diseases. As proteinopathies are caused by the aggregation of disease-typical proteins with an ordered structure, active and passive immunization protocols have been used to expose model systems to therapeutic antibodies that bind to the aggregates thereby inhibiting the prolongation into higher ordered fibrils or dissolving the existing fibrillar structure. While most of the immunization treatments have been only carried out in preclinical model systems overexpressing the disease-relevant aggregating protein, other approaches are already in clinical testing. Taking the core concept of proteinopathies with conformationally altered protein aggregates into account, immunization appears to be a very promising therapeutic option for neurodegenerative disorders.

--- ABSTRACT END ---

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(1)63 of	(12)7 as	(23)3 assessment	(34)2 demonstrated
(2)55 null	(13)6 are	(24)3 fit	(35)2 it
(3)35 for	(14)6 system	(25)3 revealed	(36)2 joints
(4)28 was	(15)5 a	(26)3 showed	(37)2 may
(5)26 to	(16)5 selection	(27)3 systems	(38)2 not
(6)16 and	(17)5 which	(28)3 were	(39)2 results
(7)16 in	(18)5 will	(29)2 allows	(40)2 species
(8)16 is	(19)4 can	(30)2 analyses	(41)2 such
(9)16 with	(20)4 parameters	(31)2 appropriate	(42)2 used
(10)12 that	(21)4 using	(32)2 biological
(11)8 the	(22)4 we	(33)2 consists

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--- WordNet output for model --- =>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする, 手本となる Overview of noun model The noun model has 9 senses (first 7 from tagged texts) 1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems") 2. (11) model -- (a type of product; "his car was an old model") 3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president didn't have time to be a model so the artist worked from photos") 4. (4) model, simulation -- (representation of something (sometimes on a smaller scale)) 5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of success"; "a model of clarity"; "he is the very model of a modern major general") 6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model") 7. (1) model, example -- (a representative form or pattern; "I profited from his example") 8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to display fashions; "she was too fat to be a mannequin") 9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale)) Overview of verb model The verb model has 6 senses (first 2 from tagged texts) 1. (1) model, pattern -- (plan or create according to a model or models) 2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay") 3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman who posed for Leonardo so often") 4. model -- (display (clothes) as a mannequin; "model the latest fashion") 5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights") 6. model, mock up -- (construct a model of; "model an airplane") Overview of adj model The adj model has 1 sense (first 1 from tagged texts) 1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens") --- WordNet end ---