2015 Medical decision making : an international journal of the Society for Medical Decision Making
* Calibration of complex models through Bayesian evidence synthesis: a demonstration and tutorial.
- Decision-analytic models must often be informed using data that are only indirectly related to the main model parameters. The authors outline how to implement a Bayesian synthesis of diverse sources of evidence to calibrate the parameters of a complex model. A graphical model is built to represent how observed data are generated from statistical models with unknown parameters and how those parameters are related to quantities of interest for decision making. This forms the basis of an algorithm to estimate a posterior probability distribution, which represents the updated state of evidence for all unknowns given all data and prior beliefs. This process calibrates the quantities of interest against data and, at the same time, propagates all parameter uncertainties to the results used for decision making. To illustrate these methods, the authors demonstrate how a previously developed Markov model for the progression of human papillomavirus (HPV-16) infection was rebuilt in a Bayesian framework. Transition probabilities between states of disease severity are inferred indirectly from cross-sectional observations of prevalence of HPV-16 and HPV-16-related disease by age, cervical cancer incidence, and other published information. Previously, a discrete collection of plausible scenarios was identified but with no further indication of which of these are more plausible. Instead, the authors derive a Bayesian posterior distribution, in which scenarios are implicitly weighted according to how well they are supported by the data. In particular, we emphasize the appropriate choice of prior distributions and checking and comparison of fitted models.
=>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする,
手本となる
Overview of noun model
The noun model has 9 senses (first 7 from tagged texts)
1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or
process; "the computer program was based on a model of the circulatory and respiratory systems")
2. (11) model -- (a type of product; "his car was an old model")
3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president
didn't have time to be a model so the artist worked from photos")
4. (4) model, simulation -- (representation of something (sometimes on a smaller scale))
5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of
success"; "a model of clarity"; "he is the very model of a modern major general")
6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model")
7. (1) model, example -- (a representative form or pattern; "I profited from his example")
8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to
display fashions; "she was too fat to be a mannequin")
9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale))
Overview of verb model
The verb model has 6 senses (first 2 from tagged texts)
1. (1) model, pattern -- (plan or create according to a model or models)
2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay")
3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman
who posed for Leonardo so often")
4. model -- (display (clothes) as a mannequin; "model the latest fashion")
5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions
simulating high-altitude flights")
6. model, mock up -- (construct a model of; "model an airplane")
Overview of adj model
The adj model has 1 sense (first 1 from tagged texts)
1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens")
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