ELIZA

return kwic search for model out of >500 occurrences
469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache] 500 found

234) We developed an in vivo vascularization model in which human endothelial colony-forming cells (ECFCs) and human mesenchymal progenitor cells (MPCs) form blood vessel networks when co-injected (ECFC + MPC) into nude mice in rat tail type I collagen, bovine fibrin or synthetic peptide PuraMatrix matrices.

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PMID:23955835 DOI:10.1002/term.1803

2015 Journal of tissue engineering and regenerative medicine

* Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices.

- We developed an in vivo vascularization model in which human endothelial colony-forming cells (ECFCs) and human mesenchymal progenitor cells (MPCs) form blood vessel networks when co-injected (ECFC + MPC) into nude mice in rat tail type I collagen, bovine fibrin or synthetic peptide PuraMatrix matrices. We used three approaches to determine the onset of functional vascularization when ECFC + MPC suspended in these matrices were implanted in vivo. The first was immunohistochemistry to detect vessels lined by human endothelial cells and filled with red blood cells. The second was in vivo vascular staining by tail vein injection of a mixture of Ulex europaeus agglutinin I (UEA-I), a lectin specific for human endothelium, and Griffonia simplicifolia isolectin B4 (GS-IB4 ), a lectin specific for rodent endothelium. The third approach employed contrast-enhanced ultrasound to measure the perfusion volumes of implants in individual animals over time. Human endothelial-lined tubular structures were detected in vivo on days 1 and 2 after implantation, with perfused human vessels detected on days 3 and 4. Contrast-enhanced ultrasound revealed significant perfusion of ECFC + MPC/collagen implants on days 1-4, at up to 14% perfused vascular volume. ECFC + MPC implanted in fibrin and PuraMatrix matrices also supported perfusion at day 1, as assessed by ultrasound (at 12% and 23% perfused vascular volume, respectively). This model demonstrates that ECFC + MPC suspended in any of the three matrices initiated a rapid onset of vascularization. We propose that ECFC + MPC delivered in vivo provide a means to achieve rapid perfusion of tissue-engineered organs or for in situ tissue repair.

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(1)63 of	(12)7 as	(23)3 assessment	(34)2 demonstrated
(2)55 null	(13)6 are	(24)3 fit	(35)2 it
(3)35 for	(14)6 system	(25)3 revealed	(36)2 joints
(4)28 was	(15)5 a	(26)3 showed	(37)2 may
(5)26 to	(16)5 selection	(27)3 systems	(38)2 not
(6)16 and	(17)5 which	(28)3 were	(39)2 results
(7)16 in	(18)5 will	(29)2 allows	(40)2 species
(8)16 is	(19)4 can	(30)2 analyses	(41)2 such
(9)16 with	(20)4 parameters	(31)2 appropriate	(42)2 used
(10)12 that	(21)4 using	(32)2 biological
(11)8 the	(22)4 we	(33)2 consists

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--- WordNet output for model --- =>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする, 手本となる Overview of noun model The noun model has 9 senses (first 7 from tagged texts) 1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems") 2. (11) model -- (a type of product; "his car was an old model") 3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president didn't have time to be a model so the artist worked from photos") 4. (4) model, simulation -- (representation of something (sometimes on a smaller scale)) 5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of success"; "a model of clarity"; "he is the very model of a modern major general") 6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model") 7. (1) model, example -- (a representative form or pattern; "I profited from his example") 8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to display fashions; "she was too fat to be a mannequin") 9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale)) Overview of verb model The verb model has 6 senses (first 2 from tagged texts) 1. (1) model, pattern -- (plan or create according to a model or models) 2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay") 3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman who posed for Leonardo so often") 4. model -- (display (clothes) as a mannequin; "model the latest fashion") 5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights") 6. model, mock up -- (construct a model of; "model an airplane") Overview of adj model The adj model has 1 sense (first 1 from tagged texts) 1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens") --- WordNet end ---