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469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache]
500 found
141) In the present study, the effects of xenoestrogen 4-nonylphenol (4-NP) and 17β-estradiol (E2) on the synthesis of vitellogenin (VTG) in immature male yellowfin seabream (Acanthoparus latus) were assessed to determine the potential use of this species as a biological model for studying endocrine disrupters in the Musa estuary in southern seawaters of Iran.
* Induction of vitellogenin synthesis in immature male yellowfin seabream (Acanthopagrus latus) exposed to 4-nonylphenol and 17β-estradiol.
- In the present study, the effects of xenoestrogen 4-nonylphenol (4-NP) and 17β-estradiol (E2) on the synthesis of vitellogenin (VTG) in immature male yellowfin seabream (Acanthoparus latus) were assessed to determine the potential use of this species as a biological model for studying endocrine disrupters in the Musa estuary in southern seawaters of Iran. A total number of 104 fish were injected by 10, 50, 100, 150 and 200 µg g(-) (1) week(-) (1) of 4-NP and 2 µg g(-) (1) week(-) (1) of E2, and their blood plasma was obtained for biochemical analysis on days 0, 7 and 14. The hepatosomatic index (HSI) of each fish was also recorded at each sampling time. The results showed that 4-NP significantly induced VTG synthesis in A. latus, which was detected by gel electrophoresis as two major protein bands (∼210 and 191 KDa). The induction of VTG was also determined indirectly by measuring the alkali-labile phosphate, total plasma calcium and protein. All of these VTG indicators significantly increased in the plasma of 4-NP- and E2-treated fish. Meanwhile, a significant dose-dependent increase was observed in HSI, indicating the activation of hepatic VTG production in 4-NP- and E2-injected fish. Furthermore, the plasma alanine aminotransferase and aspartate aminotransferase concentrations significantly increased in 4-NP-treated fish, presumably reflecting a situation of hepatic tissue damage due to 4-NP toxicity. Based on the results, it is suggested that A. latus could be used successfully as a model species for future studies of endocrine disrupting contaminants in the Musa estuary.
=>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする,
手本となる
Overview of noun model
The noun model has 9 senses (first 7 from tagged texts)
1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or
process; "the computer program was based on a model of the circulatory and respiratory systems")
2. (11) model -- (a type of product; "his car was an old model")
3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president
didn't have time to be a model so the artist worked from photos")
4. (4) model, simulation -- (representation of something (sometimes on a smaller scale))
5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of
success"; "a model of clarity"; "he is the very model of a modern major general")
6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model")
7. (1) model, example -- (a representative form or pattern; "I profited from his example")
8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to
display fashions; "she was too fat to be a mannequin")
9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale))
Overview of verb model
The verb model has 6 senses (first 2 from tagged texts)
1. (1) model, pattern -- (plan or create according to a model or models)
2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay")
3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman
who posed for Leonardo so often")
4. model -- (display (clothes) as a mannequin; "model the latest fashion")
5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions
simulating high-altitude flights")
6. model, mock up -- (construct a model of; "model an airplane")
Overview of adj model
The adj model has 1 sense (first 1 from tagged texts)
1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens")
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