ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for method out of >500 occurrences
375291 occurrences (No.49 in the rank) during 5 years in the PubMed. [cache]
437) Method 3 was non-discriminatory giving a DT of 13-15 s for all formulations.
--- ABSTRACT ---
PMID:24397821 DOI:10.3109/10837450.2013.871031
2015 Pharmaceutical development and technology
* Influence of Prosolv and Prosolv:Mannitol 200 direct compression fillers on the physicomechanical properties of atorvastatin oral dispersible tablets.
- The objective of the present study was to evaluate the influence of Prosolv® and Prosolv®: Mannitol 200 direct compression (DC) fillers on the physicomechanical characteristics of oral dispersible tablets (ODTs) of crystalline atorvastatin calcium. ODTs were formulated by DC and were analyzed for weight uniformity, hardness, friability, drug content, disintegration and dissolution. Three disintegration time (DT) test methods; European Pharmacopoeia (EP) method for conventional tablets (Method 1), a modification of this method (Method 2) and the EP method for oral lyophilisates (Method 3) were compared as part of this study. All ODTs showed low weight variation of <2.5%. Prosolv® only ODTs showed the highest tablet hardness of ∼ 73 N, hardness decreased with increasing mannitol content. Friability of all formulations was <1% although friability of Prosolv®:Mannitol ODTs was higher than for pure Prosolv®. DT of all ODTs was <30 s. Method 2 showed the fastest DT. Method 3 was non-discriminatory giving a DT of 13-15 s for all formulations. Atorvastatin dissolution from all ODTs was >60% within 5 min despite the drug being crystalline. Prosolv® and Prosolv®:Mannitol-based ODTs are suitable for ODT formulations by DC to give ODTs with high mechanical strength, rapid disintegration and dissolution.
[frequency of next (right) word to method]
(1)81 *null* (12)7 with (23)2 allowed (34)2 may
(2)59 for (13)6 using (24)2 among (35)2 on
(3)39 of (14)5 has (25)2 but (36)2 provided
(4)39 to (15)5 used (26)2 by (37)2 should
(5)37 was (16)4 showed (27)2 choice (38)2 study
(6)26 is (17)4 which (28)2 combined (39)2 the
(7)24 and (18)3 are (29)2 could (40)2 uses
(8)15 in (19)3 as (30)2 from (41)2 we
(9)9 that (20)3 significantly (31)2 helped
(10)8 can (21)2 a (32)2 involves
(11)7 based (22)2 against (33)2 known

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--- WordNet output for method --- =>方法, 筋道, 秩序, 規則正しさ, 順序 Overview of noun method The noun method has 2 senses (first 1 from tagged texts) 1. (95) method -- (a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)) 2. method acting, method -- (an acting technique introduced by Stanislavsky in which the actor recalls emotions or reactions from his or her own life and uses them to identify with the character being portrayed) --- WordNet end ---