ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for method out of >500 occurrences
375291 occurrences (No.49 in the rank) during 5 years in the PubMed. [no cache] 500 found
102) This work focuses on the evaluation of a method for determining MNZ in water, sediment and fish tissue samples using liquid chromatography--ion trap mass spectrometry (LC-MS/MS).
--- ABSTRACT ---
PMID:24412503 DOI:10.1016/j.chemosphere.2013.12.061
2015 Chemosphere
* Determination of metronidazole residues in water, sediment and fish tissue samples.
- Metronidazole (MNZ) is an antibacterial and antiprotozoal drug used in veterinary and human medicine. Its continual entry into the environment and its biological properties may have significant, long-term effects on the stability of ecosystems because MNZ and its metabolites possess mutagenic, carcinogenic and toxic properties. For this reason, the application of MNZ in food-producing species is prohibited in the EU, the USA and other countries. To ensure human food safety and to protect the environment, robust and reliable screening and confirmatory tests capable of the low-level detection of MNZ residues are required. The development of methods for MNZ determination in biological and environmental samples is thus an important analytical task in environmental and food science. This work focuses on the evaluation of a method for determining MNZ in water, sediment and fish tissue samples using liquid chromatography--ion trap mass spectrometry (LC-MS/MS). MNZ was extracted from waters on Strata XC cartridges using solid phase extraction (SPE), and from sediments and fish tissues by solid-liquid extraction (sediment: 15 mL 0.1 M HCl (pH=0.6), 15 min; fish tissue: 15 mL 1% CH3COOH in ACN, 1 min; drying: 5 g MgSO4(anhyd.; 30 s) with SPE purification of the extracts (from sediment: Strata XC cartridge; from fish tissue: Supelco NH2 cartridge). The optimal procedure that we developed was validated in order to confirm its reliability and sensitivity. Matrix effects (ME) were established. Absolute recoveries ranged from 89.3% to 97.2%, and the method detection limits were 3.4 ng L(-1) (water samples), 0.4 ng g(-1) (sediment samples) and 0.3 ng g(-1) (tissue samples). These methods were used to determine MNZ in surface waters, sediments and fish tissues from the Polish River Gościcina; MNZ was found in all these matrices. The highest concentrations in water, sediment and tissue were 136.2 ng L(-1), 12.0 ng g(-1) and 1.5 ng g(-1) respectively. The results confirmed that these methods are suitable for the simultaneous analysis of waters, sediments and fish tissues for the presence of MNZ.
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(1)81 *null* (12)7 with (23)2 allowed (34)2 may
(2)59 for (13)6 using (24)2 among (35)2 on
(3)39 of (14)5 has (25)2 but (36)2 provided
(4)39 to (15)5 used (26)2 by (37)2 should
(5)37 was (16)4 showed (27)2 choice (38)2 study
(6)26 is (17)4 which (28)2 combined (39)2 the
(7)24 and (18)3 are (29)2 could (40)2 uses
(8)15 in (19)3 as (30)2 from (41)2 we
(9)9 that (20)3 significantly (31)2 helped
(10)8 can (21)2 a (32)2 involves
(11)7 based (22)2 against (33)2 known

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--- WordNet output for method --- =>方法, 筋道, 秩序, 規則正しさ, 順序 Overview of noun method The noun method has 2 senses (first 1 from tagged texts) 1. (95) method -- (a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)) 2. method acting, method -- (an acting technique introduced by Stanislavsky in which the actor recalls emotions or reactions from his or her own life and uses them to identify with the character being portrayed) --- WordNet end ---