ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for lower out of >500 occurrences
288686 occurrences (No.85 in the rank) during 5 years in the PubMed. [cache]
65) Protein level of vimentin was significantly lower in the MDA-MB-231 xenografts as well as in MMTV-neu tumors from WA-treated mice compared with controls.
* Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.
- We have shown previously that withaferin A (WA), a bioactive component of the medicinal plant Withania somnifera, inhibits growth of cultured and xenografted human breast cancer cells and prevents breast cancer development and pulmonary metastasis incidence in a transgenic mouse model. The present study was undertaken to determine if the anticancer effect of WA involved inhibition of epithelial-mesenchymal transition (EMT). Experimental EMT induced by exposure of MCF-10A cells to tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β) was partially reversed by treatment with WA but not by its structural analogs withanone or withanolide A. Combined TNF-α and TGF-β treatments conferred partial protection against MCF-10A cell migration inhibition by WA. Inhibition of TNF-α and TGF-β-induced MCF-10A cell migration by WA exposure was modestly attenuated by knockdown of E-cadherin protein. MCF-7 and MDA-MB-231 cells exposed to WA exhibited sustained (MCF-7) or transient (MDA-MB-231) induction of E-cadherin protein. On the other hand, the level of vimentin protein was increased markedly after 24 h treatment of MDA-MB-231 cells with WA. WA-induced apoptosis was not affected by vimentin protein knockdown in MDA-MB-231 cells. Protein level of vimentin was significantly lower in the MDA-MB-231 xenografts as well as in MMTV-neu tumors from WA-treated mice compared with controls. The major conclusions of the present study are that (a) WA treatment inhibits experimental EMT in MCF-10A cells, and (b) mammary cancer growth inhibition by WA administration is associated with suppression of vimentin protein expression in vivo.
=>1.低くする/なる, 下げる/下がる, 卑しめる, 2.しかめっ面, 3.lowの比較級
Overview of noun lower
The noun lower has 1 sense (no senses from tagged texts)
1. lower berth, lower -- (the lower of two berths)
Overview of verb lower
The verb lower has 5 senses (first 3 from tagged texts)
1. (15) lower, take down, let down, get down, bring down -- (move something or somebody to a lower
position; "take down the vase from the shelf")
2. (6) lower, lour -- (set lower; "lower a rating"; "lower expectations")
3. (1) turn down, lower, lour -- (make lower or quieter; "turn down the volume of a radio")
4. lower, depress -- (cause to drop or sink; "The lack of rain had depressed the water level in the
reservoir")
5. frown, glower, lour, lower -- (look angry or sullen, wrinkle one's forehead, as if to signal
disapproval)
Overview of adj low
The adj low has 10 senses (first 6 from tagged texts)
1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is
low")
2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward
extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low
bow")
3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf")
4. (6) low -- (unrefined in character; "low comedy")
5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency)
6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject
cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You
miserable skunk!"; "a scummy rabble"; "a scurvy trick")
7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage";
"a lowly parish priest"; "a modest man of the people"; "small beginnings")
8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted")
9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status;
"brought low"; "a broken man"; "his broken spirit")
10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low,
low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to
face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening
mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and
resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and
downhearted")
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