* Validation of the revised International Criteria for Behcet's Disease (ICBD) in Iran.
- The first internationally agreed criteria for Behcet's disease were the International Study Group (ISG) criteria. It had very high specificity, but lacked good sensitivity, missing an important subset of patients. The International Criteria for Behcet's Disease (ICBD) were created in 2006 to overcome this lack of sensitivity. It was revised in 2010. The objective of this study was to evaluate the performance of the revised International Criteria for Behcet's Disease (rICBD) in Iran. In this study, the ISG and ICBD were evaluated and compared to the rICBD. All patients from the Behcet's Disease Registry (7,011) and controls (5,226), up to March 2013, entered the study. The diagnosis was clinical, by expert opinion. Sensitivity, specificity, and accuracy were calculated for ISG, ICBD, and rICBD. A 95% confidence interval (95%CI) was calculated for percentages. For ISG, the sensitivity was 77.5% (95%CI = 76.5-78.5). It was 98.3% for ICBD (95%CI = 98.0-98.6) and 96.8% for rICBD (95%CI = 96.4-97.2). Specificity was 99.2% (95%CI = 99.0-99.4) for ISG, 96.2% for ICBD (95%CI = 95.7-96.7), and 97.2% for rICBD (95%CI = 96.8-97.6). Accuracy was 86.7% (95%CI = 86.1-87.3) for ISG, 97.4% for ICBD (95%CI = 97.1-97.7), and 97.0% for rICBD (95%CI = 96.7-97.3). In Iranian patients, ICBD has 20.8% and rICBD 19.3% higher sensitivity than ISG. Although the specificity was lower than ISG by 3% for ICBD and 2% for rICBD, the accuracy was higher respectively by 10.7 and 10.3%. ICBD has by far better performance than ISG. The difference was even more prominent in Iranian patients than for the ICBD cohort of patients and controls.
=>1.低くする/なる, 下げる/下がる, 卑しめる, 2.しかめっ面, 3.lowの比較級
Overview of noun lower
The noun lower has 1 sense (no senses from tagged texts)
1. lower berth, lower -- (the lower of two berths)
Overview of verb lower
The verb lower has 5 senses (first 3 from tagged texts)
1. (15) lower, take down, let down, get down, bring down -- (move something or somebody to a lower
position; "take down the vase from the shelf")
2. (6) lower, lour -- (set lower; "lower a rating"; "lower expectations")
3. (1) turn down, lower, lour -- (make lower or quieter; "turn down the volume of a radio")
4. lower, depress -- (cause to drop or sink; "The lack of rain had depressed the water level in the
reservoir")
5. frown, glower, lour, lower -- (look angry or sullen, wrinkle one's forehead, as if to signal
disapproval)
Overview of adj low
The adj low has 10 senses (first 6 from tagged texts)
1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is
low")
2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward
extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low
bow")
3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf")
4. (6) low -- (unrefined in character; "low comedy")
5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency)
6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject
cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You
miserable skunk!"; "a scummy rabble"; "a scurvy trick")
7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage";
"a lowly parish priest"; "a modest man of the people"; "small beginnings")
8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted")
9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status;
"brought low"; "a broken man"; "his broken spirit")
10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low,
low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to
face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening
mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and
resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and
downhearted")
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