ELIZA

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288686 occurrences (No.85 in the rank) during 5 years in the PubMed. [no cache] 500 found

331) The lower MR for 5-hydroxy omeprazole and omeprazole sulphone in follicular phase as compared to luteal phase suggests that metabolism of omeprazole is low in follicular phase as compared to luteal phase, which is progesterone-dominant phase.

--- ABSTRACT ---

PMID:24390778 DOI:10.1007/s13318-013-0167-4

2015 European journal of drug metabolism and pharmacokinetics

* Pharmacokinetics of omeprazole and its metabolites in three phases of menstrual cycle.

- Omeprazole (OMP) is effective in the treatment of gastric hyperacidity and is metabolized by CYP2C19 and CYP3A4. These enzymes are modulated by estrogen and progesterone which regulate the menstrual cycle. The variations in the pharmacokinetics (PK) of many drugs like amphetamine, benzodiazepines and caffeine have been reported during menstrual cycle. In present study, the PK of the omeprazole and its metabolites was investigated during various phases of the menstrual cycle. A single oral dose, open-label, non-controlled, pharmacokinetic study of omeprazole was conducted in healthy young/premenopausal females (n = 16). The PK of omeprazole, 5-hydroxy-omeprazole and omeprazole sulphone was evaluated in three phases of menstrual cycle. The blood samples were analyzed using reversed-phase HPLC coupled with UV detector and the PK data were evaluated. The activities of CYP2C19 and CYP3A4 were determined as AUC(OH-OMP)/AUC(OMP) and AUC(OMP-SUL)/AUC(OMP), respectively. Omeprazole showed significantly (p < 0.05) higher [Formula: see text] and CL/F in follicular and menstrual phases, respectively. The [Formula: see text] of 5-hydroxy omeprazole was also significantly (p < 0.05) higher in follicular phase. The metabolic ratios (MR) of 5-hydroxy omeprazole and omeprazole sulphone were lower in follicular phase compared with the luteal phase. The present study suggests that high estrogen levels of follicular phase may result in increased absorption of omeprazole. The lower MR for 5-hydroxy omeprazole and omeprazole sulphone in follicular phase as compared to luteal phase suggests that metabolism of omeprazole is low in follicular phase as compared to luteal phase, which is progesterone-dominant phase. However, the clinical significance for these findings needs to be determined.

--- ABSTRACT END ---

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(1)38 than	(19)4 incidence	(37)3 socioeconomic	(55)2 expression
(2)35 in	(20)4 leg	(38)3 stresses	(56)2 eyelid
(3)19 levels	(21)4 spine	(39)3 values	(57)2 eyelids
(4)12 extremity	(22)4 total	(40)2 Condom	(58)2 frequencies
(5)11 risk	(23)3 (P	(41)2 EI	(59)2 frequency
(6)7 compared	(24)3 null	(42)2 IQ	(60)2 likelihood
(7)7 level	(25)3 ASM/wt	(43)2 abdominal	(61)2 limit
(8)7 limb	(26)3 education	(44)2 among	(62)2 microleakage
(9)5 at	(27)3 educational	(45)2 back	(63)2 perceived
(10)5 for	(28)3 extremities,	(46)2 birthweight	(64)2 percentage
(11)5 limbs	(29)3 heart	(47)2 bounds	(65)2 quality
(12)5 the	(30)3 initial	(48)2 by	(66)2 rate
(13)4 and	(31)3 legs	(49)2 complication	(67)2 resilience
(14)4 body	(32)3 mean	(50)2 concentration	(68)2 serum
(15)4 cervical	(33)3 odds	(51)2 concentrations	(69)2 shear
(16)4 dose	(34)3 prevalence	(52)2 demineralization
(17)4 doses	(35)3 probability	(53)2 esophageal
(18)4 extremities	(36)3 sexual	(54)2 estimated

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--- WordNet output for lower --- =>1.低くする/なる, 下げる/下がる, 卑しめる, 2.しかめっ面, 3.lowの比較級 Overview of noun lower The noun lower has 1 sense (no senses from tagged texts) 1. lower berth, lower -- (the lower of two berths) Overview of verb lower The verb lower has 5 senses (first 3 from tagged texts) 1. (15) lower, take down, let down, get down, bring down -- (move something or somebody to a lower position; "take down the vase from the shelf") 2. (6) lower, lour -- (set lower; "lower a rating"; "lower expectations") 3. (1) turn down, lower, lour -- (make lower or quieter; "turn down the volume of a radio") 4. lower, depress -- (cause to drop or sink; "The lack of rain had depressed the water level in the reservoir") 5. frown, glower, lour, lower -- (look angry or sullen, wrinkle one's forehead, as if to signal disapproval) Overview of adj low The adj low has 10 senses (first 6 from tagged texts) 1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is low") 2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow") 3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf") 4. (6) low -- (unrefined in character; "low comedy") 5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency) 6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You miserable skunk!"; "a scummy rabble"; "a scurvy trick") 7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage"; "a lowly parish priest"; "a modest man of the people"; "small beginnings") 8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted") 9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status; "brought low"; "a broken man"; "his broken spirit") 10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low, low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and downhearted") --- WordNet end ---