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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for low out of >500 occurrences
318584 occurrences (No.68 in the rank) during 5 years in the PubMed. [no cache] 500 found
237) It has been reported that cholesterol-rich nanoemulsions (LDE) can bind to low density lipoprotein (LDL) receptors which can concentrate anticancer drugs in the tissues via LDL receptor overexpression and reduced the adverse effects of the treatment.
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PMID:24266739 DOI:10.3109/10837450.2013.860551
2015 Pharmaceutical development and technology
* Formulation and evaluation of cholesterol-rich nanoemulsion (LDE) for drug delivery potential of cholesteryl-maleoyl-5-fluorouracil.
- It has been reported that cholesterol-rich nanoemulsions (LDE) can bind to low density lipoprotein (LDL) receptors which can concentrate anticancer drugs in the tissues via LDL receptor overexpression and reduced the adverse effects of the treatment. Therefore, in this study, LDE nanoemulsions of cholesteryl-maleoyl-5-fluorouracil (5-FU conjugate) were developed and evaluated in vitro. LDE nanoemulsions were prepared by high-energy emulsification technique. Developed formulations were characterized in terms of droplet size, polydispersity index, zeta potential, viscosity and refractive index. Optimized formulation (L5) was also evaluated for surface morphology using transmission electron microscopy (TEM). Developed formulations were subjected to in vitro drug release studies through dialysis membrane. The droplet size (50 nm), polydispersity index (0.109) and viscosity (32.16 cp) were found to be lowest for optimized formulation L5. The results of zeta potential indicated the stable formation of developed LDE nanoemulsions. TEM images of optimized formulation indicated non-spherical shape of droplets. About 97% of conjugate was found to be released from L5 after 24 h of study. Overall, these results indicated that developed LDE nanoemulsions could be successfully used for oral delivery of 5-FU conjugate.
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[frequency of next (right) word to low]
(1)21 and (18)4 or (35)2 Chilean (52)2 energy
(2)19 laser (19)4 socioeconomic (36)2 HLB (53)2 families
(3)11 doses (20)3 Er:YAG (37)2 OAs (54)2 genetic
(4)11 levels (21)3 O2 (38)2 acculturation (55)2 group
(5)10 *null* (22)3 PFR (39)2 activities (56)2 maternal
(6)10 cost (23)3 PbB (40)2 activity (57)2 method
(7)10 lipoprotein (24)3 STT (41)2 after (58)2 molecular
(8)8 back (25)3 concentrations (42)2 areas (59)2 oral
(9)8 birth (26)3 educational (43)2 at (60)2 pH
(10)8 dose (27)3 features (44)2 bioavailability (61)2 peer
(11)7 in (28)3 risk (45)2 body (62)2 population
(12)7 level (29)3 serum (46)2 cancer (63)2 radiation
(13)6 birthweight (30)3 shear (47)2 children (64)2 resilience
(14)5 but (31)3 tumours (48)2 coverage (65)2 running
(15)4 as (32)3 vagal (49)2 degree (66)2 sensitivity
(16)4 carbon (33)3 water (50)2 density (67)2 settings
(17)4 income (34)3 whole-body (51)2 education (68)2 temperature

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--- WordNet output for low --- =>安い, 低いところ, 卑劣に, 粗食で, 低い(もの), 弱い, 粗末な, 乏しい, 衿ぐりが深い, 建物の低い, 下劣な, 低級な Overview of noun low The noun low has 4 senses (no senses from tagged texts) 1. low, depression -- (an air mass of lower pressure; often brings precipitation; "a low moved in over night bringing sleet and snow") 2. Low, David Low, Sir David Low, Sir David Alexander Cecil Low -- (British political cartoonist (born in New Zealand) who created the character Colonel Blimp (1891-1963)) 3. low -- (a low level or position or degree; "the stock market fell to a new low") 4. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor vehicle; used to start a car moving) Overview of verb low The verb low has 1 sense (no senses from tagged texts) 1. moo, low -- (make a low noise, characteristic of bovines) Overview of adj low The adj low has 10 senses (first 6 from tagged texts) 1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is low") 2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow") 3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf") 4. (6) low -- (unrefined in character; "low comedy") 5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency) 6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You miserable skunk!"; "a scummy rabble"; "a scurvy trick") 7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage"; "a lowly parish priest"; "a modest man of the people"; "small beginnings") 8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted") 9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status; "brought low"; "a broken man"; "his broken spirit") 10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low, low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and downhearted") Overview of adv low The adv low has 1 sense (first 1 from tagged texts) 1. (3) low -- (in a low position; near the ground; "the branches hung low") --- WordNet end ---