90) Giant congenital melanocytic nevi (GCMN) occur in 1:20,000 livebirths and are associated with increased risk of malignant transformation. |
PMID:23903082 DOI:10.1097/SAP.0b013e3182920c3d |
2015 Annals of plastic surgery |
* Giant congenital melanocytic nevus: report from 30 years of experience in a single department. |
- Giant congenital melanocytic nevi (GCMN) occur in 1:20,000 livebirths and are associated with increased risk of malignant transformation. The treatment of GCMN from 1981 to 2010 in a tertiary referral center was reviewed evaluating the modalities used, cosmetic results, associated complications, and malignant transformation. Of 35 patients, 25 underwent surgery. Curettage was most frequently used (64%) followed by excision and tissue expansion (20%). Six percent of the patients treated with curettage, and 78% of the patients who received excision surgery required more than 1 planned procedure, and 25% versus 44% required unplanned additional surgery, respectively. Complications were noted in 25% and 67% of the patients, respectively. Cosmetic result was satisfying in 76% of patients without difference between the groups. No malignant transformation was found during a mean follow-up of 11 years. Curettage is a gentle alternative to excision with a lower complication rate and good cosmetic outcome. |
(1)36 the | (14)5 to | (27)2 RDW | (40)2 likelihood |
(2)34 in | (15)4 after | (28)2 awareness | (41)2 maternal |
(3)27 risk | (16)4 as | (29)2 bone | (42)2 morbidity |
(4)21 *null* | (17)3 activity | (30)2 but | (43)2 number |
(5)20 with | (18)3 among | (31)2 compared | (44)2 over |
(6)16 by | (19)3 at | (32)2 concentrations | (45)2 pre-stimulus |
(7)15 significantly | (20)3 cell | (33)2 drug | (46)2 production |
(8)6 and | (21)3 level | (34)2 during | (47)2 rapidly |
(9)6 expression | (22)3 levels | (35)2 fax | (48)2 use |
(10)6 from | (23)3 physical | (36)2 functional | (49)2 vascular |
(11)5 activation | (24)3 sensitivity | (37)2 hepatic | |
(12)5 odds | (25)2 MI | (38)2 if | |
(13)5 serum | (26)2 Math1 | (39)2 interest |
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