306) Human and feline OSCC cell lines expressed COX-1 and COX-2 and the SCCF2 cells had increased COX-2 mRNA expression with bone conditioned medium. |
PMID:23651067 DOI:10.1111/vco.12037 |
2015 Veterinary and comparative oncology |
* Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma. |
- Oral squamous cell carcinoma (OSCC) is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase (COX)-2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumour growth, osteolysis and invasion in feline OSCC xenografts in mice. Human and feline OSCC cell lines expressed COX-1 and COX-2 and the SCCF2 cells had increased COX-2 mRNA expression with bone conditioned medium. Luciferase-expressing feline SCCF2Luc cells were injected beneath the perimaxillary gingiva and mice were treated with 0.1 mg kg(-1) ZOL twice weekly, 0.3 mg kg(-1) meloxicam daily, combined ZOL and meloxicam, or vehicle. ZOL inhibited osteoclastic bone resorption at the tumour-bone interface. Meloxicam was more effective than ZOL at reducing xenograft growth but did not affect osteoclastic bone resorption. Although a synergistic effect of combined ZOL and meloxicam was not observed, combination therapy was well-tolerated and may be useful in the clinical management of bone-invasive feline OSCC. |
(1)36 the | (14)5 to | (27)2 RDW | (40)2 likelihood |
(2)34 in | (15)4 after | (28)2 awareness | (41)2 maternal |
(3)27 risk | (16)4 as | (29)2 bone | (42)2 morbidity |
(4)21 *null* | (17)3 activity | (30)2 but | (43)2 number |
(5)20 with | (18)3 among | (31)2 compared | (44)2 over |
(6)16 by | (19)3 at | (32)2 concentrations | (45)2 pre-stimulus |
(7)15 significantly | (20)3 cell | (33)2 drug | (46)2 production |
(8)6 and | (21)3 level | (34)2 during | (47)2 rapidly |
(9)6 expression | (22)3 levels | (35)2 fax | (48)2 use |
(10)6 from | (23)3 physical | (36)2 functional | (49)2 vascular |
(11)5 activation | (24)3 sensitivity | (37)2 hepatic | |
(12)5 odds | (25)2 MI | (38)2 if | |
(13)5 serum | (26)2 Math1 | (39)2 interest |
add keyword