ELIZA

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611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [no cache] 500 found

279) The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting.

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PMID:24297467 DOI:10.1007/s00702-013-1128-4

2015 Journal of neural transmission (Vienna, Austria : 1996)

* Novel putative mechanisms to link circadian clocks to healthy aging.

- The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.

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(1)259 in	(7)6 during	(13)3 drug	(19)2 ROM
(2)55 the	(8)5 was	(14)3 from	(20)2 between
(3)36 of	(9)5 with	(15)3 or	(21)2 chlamydia
(4)10 null	(10)4 life	(16)3 susceptibility	(22)2 could
(5)7 physical	(11)3 at	(17)3 their	(23)2 observed
(6)6 and	(12)3 awareness	(18)2 (P	(24)2 our

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--- WordNet output for increase --- =>大きくなる, を増す, 増大させる, 強まる, 増加, 増える, 増やす Overview of noun increase The noun increase has 5 senses (first 5 from tagged texts) 1. (49) addition, increase, gain -- (a quantity that is added; "there was an addition to property taxes this year"; "they recorded the cattle's gain in weight over a period of weeks") 2. (21) increase -- (a change resulting in an increase; "the increase is scheduled for next month") 3. (7) increase, increment, growth -- (a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population") 4. (3) increase, increment -- (the amount by which something increases; "they proposed an increase of 15 percent in the fare") 5. (3) increase, step-up -- (the act of increasing something; "he gave me an increase in salary") Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") --- WordNet end ---