ELIZA

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468001 occurrences (No.36 in the rank) during 5 years in the PubMed. [no cache] 500 found

9) We show that that all regions of the peptide are rigid, including the N-terminal part often believed to be flexible in Aβ wt.

--- ABSTRACT ---

PMID:24395155 DOI:10.1007/s12104-013-9535-x

2015 Biomolecular NMR assignments

* Solid-state NMR sequential assignment of Osaka-mutant amyloid-beta (Aβ1-40 E22Δ) fibrils.

- Alzheimer's disease (AD) is the most common form of dementia. Aggregation of amyloid β (Aβ), a peptide of 39-43 residues length, into insoluble fibrils is considered to initiate the disease. Determination of the molecular structure of Aβ fibrils is technically challenging and is a significant goal in AD research that may lead to design of effective therapeutical inhibitors of Aβ aggregation. Here, we present chemical-shift assignments for fibrils formed by highly pure recombinant Aβ1-40 with the Osaka E22Δ mutation that is found in familial AD. We show that that all regions of the peptide are rigid, including the N-terminal part often believed to be flexible in Aβ wt.

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(1)55 the	(10)3 all	(20)2 an	(29)2 lower
(2)28 13	(11)3 cell	(21)2 angiogenesis,	(30)2 lung
(3)11 a	(12)3 our	(22)2 appropriate	(31)2 many
(4)7 those	(13)3 reduced	(23)2 autism	(32)2 questions
(5)5 in	(14)3 their	(24)2 changes	(33)2 studies
(6)5 its	(15)3 three	(25)2 depression,	(34)2 topical
(7)4 2	(17)2 3	(26)2 improved	(35)2 two
(8)4 both	(18)2 37	(27)2 increased
(9)3 age,	(19)2 activated	(28)2 induction

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--- WordNet output for including --- =>含む Overview of verb include The verb include has 4 senses (first 4 from tagged texts) 1. (234) include -- (have as a part, be made up out of; "The list includes the names of many famous writers") 2. (32) include -- (consider as part of something; "I include you in the list of culprits") 3. (18) include -- (add as part of something else; put in as part of a set, group, or category; "We must include this chemical element in the group") 4. (8) admit, let in, include -- (allow participation in or the right to be part of; permit to exercise the rights, functions, and responsibilities of; "admit someone to the profession"; "She was admitted to the New Jersey Bar") --- WordNet end ---