ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found
5) Taken together, our findings reveal that ANXA3 might play an important role in HCC progression and chemoresistance, and could serve as a novel prognostic marker and therapeutic target for HCC.
--- ABSTRACT ---
PMID:24375474 DOI:10.1002/mc.22126
2015 Molecular carcinogenesis
* Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma.
- Annexin A3 (ANXA3) has been found to play important roles in cancer progression, metastasis, and drug resistance; however, its role in hepatocellular carcinoma (HCC) remains unknown. In this study, we investigated the expression level, clinical significance and biologic function of ANXA3 in HCC. Real-time quantitative reverse transcriptase-polymerase chain reaction, western blotting and immunohistochemical staining were used to examine ANXA3 expression levels in HCC tumor tissue, and its correlation with the clinicopathological features and prognosis of HCC patients was analyzed. The biological functions of ANXA3 in cell proliferation, migration, invasion, and resistance to chemotherapy were also investigated. ANXA3 expression was significantly increased in HCC tissues as compared with adjacent non-tumorous tissues. Elevated ANXA3 expression was associated with tumor size, number of lesions, tumor stage, and poor prognosis. In hepatoma cell lines, exogenous ANXA3 transduction promoted the tumorigenic activity and metastatic potential of tumor cells. Small interfering RNA silencing of ANXA3 inhibited these processes. In addition, in vitro and in vivo experiments revealed that ANXA3 overexpression enhanced resistance to chemotherapy. Taken together, our findings reveal that ANXA3 might play an important role in HCC progression and chemoresistance, and could serve as a novel prognostic marker and therapeutic target for HCC.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to important]
(1)65 role (16)4 data (31)2 alternative (46)2 indicator
(2)37 for (17)4 differences (32)2 aspect (47)2 mechanism
(3)34 to (18)3 approach (33)2 baseline (48)2 model
(4)28 in (19)3 causes (34)2 because (49)2 molecular
(5)15 implications (20)3 clinical (35)2 bivalve, (50)2 not
(6)11 factor (21)3 findings (36)2 complication (51)2 pathogen
(7)9 *null* (22)3 genes (37)2 components (52)2 phenomenon
(8)9 and (23)3 health (38)2 consequences (53)2 physiological
(9)8 determinants (24)3 human (39)2 contributor (54)2 protective
(10)8 roles (25)3 insights (40)2 coping (55)2 route
(11)7 factors (26)3 policy (41)2 determinant (56)2 standard
(12)6 cause (27)3 predictors (42)2 economic (57)2 step
(13)5 component (28)3 public (43)2 element (58)2 strategic
(14)5 risk (29)3 when (44)2 fish (59)2 subset
(15)4 as (30)2 DNA (45)2 function (60)2 target

add keyword

--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---