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return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found

367) Therefore, anidulafungin is an important antifungal treatment option for patients with liver dysfunction.

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PMID:23797458 DOI:10.1007/s00063-013-0262-y

2015 Medizinische Klinik, Intensivmedizin und Notfallmedizin

* [Liver dysfunctions in intensive care patients--consequences for the treatment of invasive Candida infections].

- Liver dysfunction is common among patients on intensive care units (ICU) due to sepsis, chronic liver disease, ischemic hepatitis, drug toxicity and intensive care measures. Critically ill patients with invasive fungal infections should therefore be treated with antifungals that are not metabolized by the liver. This may help to avoid therapeutic complications by drug accumulation, inadequate dosages or drug-drug interactions. Echinocandins are established as the antifungal class of choice in the treatment of invasive Candida infections. Anidulafungin is not hepatically metabolized and may be used without dose adjustments in patients with severe liver dysfunction. It has no known clinically relevant drug interactions. In the primary endpoint of the randomized pivotal trial in patients with candidemia or invasive candidiasis, anidulafungin was statistically superior versus the former standard therapy (fluconazole), with a favourable overall safety profile. More recent study data particularly in ICU patients confirm the efficacy of anidulafungin for these patient groups. Therefore, anidulafungin is an important antifungal treatment option for patients with liver dysfunction.

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(1)65 role	(16)4 data	(31)2 alternative	(46)2 indicator
(2)37 for	(17)4 differences	(32)2 aspect	(47)2 mechanism
(3)34 to	(18)3 approach	(33)2 baseline	(48)2 model
(4)28 in	(19)3 causes	(34)2 because	(49)2 molecular
(5)15 implications	(20)3 clinical	(35)2 bivalve,	(50)2 not
(6)11 factor	(21)3 findings	(36)2 complication	(51)2 pathogen
(7)9 null	(22)3 genes	(37)2 components	(52)2 phenomenon
(8)9 and	(23)3 health	(38)2 consequences	(53)2 physiological
(9)8 determinants	(24)3 human	(39)2 contributor	(54)2 protective
(10)8 roles	(25)3 insights	(40)2 coping	(55)2 route
(11)7 factors	(26)3 policy	(41)2 determinant	(56)2 standard
(12)6 cause	(27)3 predictors	(42)2 economic	(57)2 step
(13)5 component	(28)3 public	(43)2 element	(58)2 strategic
(14)5 risk	(29)3 when	(44)2 fish	(59)2 subset
(15)4 as	(30)2 DNA	(45)2 function	(60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---