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return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found

365) Knockout mice are important animal models for studying the role of genes during palatal development.

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PMID:23851369 DOI:10.1097/SAP.0b013e318295dcb8

2015 Annals of plastic surgery

* Targeted mutations of genes reveal important roles in palatal development in mice.

- The process of palatal development is regulated by growth factors, extracellular matrix (ECM) protein, and cell adhesion molecules, of which disturbance may result in cleft palate. Knockout mice are important animal models for studying the role of genes during palatal development. Therefore, in this review, we will describe genes knockout in mice to reveal the biological mechanisms of these genes in the formation of the cleft palate.

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(1)65 role	(16)4 data	(31)2 alternative	(46)2 indicator
(2)37 for	(17)4 differences	(32)2 aspect	(47)2 mechanism
(3)34 to	(18)3 approach	(33)2 baseline	(48)2 model
(4)28 in	(19)3 causes	(34)2 because	(49)2 molecular
(5)15 implications	(20)3 clinical	(35)2 bivalve,	(50)2 not
(6)11 factor	(21)3 findings	(36)2 complication	(51)2 pathogen
(7)9 null	(22)3 genes	(37)2 components	(52)2 phenomenon
(8)9 and	(23)3 health	(38)2 consequences	(53)2 physiological
(9)8 determinants	(24)3 human	(39)2 contributor	(54)2 protective
(10)8 roles	(25)3 insights	(40)2 coping	(55)2 route
(11)7 factors	(26)3 policy	(41)2 determinant	(56)2 standard
(12)6 cause	(27)3 predictors	(42)2 economic	(57)2 step
(13)5 component	(28)3 public	(43)2 element	(58)2 strategic
(14)5 risk	(29)3 when	(44)2 fish	(59)2 subset
(15)4 as	(30)2 DNA	(45)2 function	(60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---