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448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found

364) Early detection of RF susceptibility is considered as an important aim of this study.

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PMID:23315088 DOI:10.1177/0748233712471701

2015 Toxicology and industrial health

* Fibronectin in the palatine tonsil as a susceptibility marker in Egyptian rheumatic families: histological and immunohistochemical studies.

- Rheumatic fever (RF) and rheumatic heart disease (RHD) are the multisystem autoimmune sequel of group A streptococci (GAS) infection of the upper respiratory passages, mainly tonsillopharyngitis. The major receptor on the surface of human palatine tonsil for GAS is fibronectin (FN; adhesin receptor). Early detection of RF susceptibility is considered as an important aim of this study. Therefore, the present study aimed to use FN immunoreactivity (FN-ir) as a marker for early detection of rheumatic susceptible children with palatine tonsil crypts surface epithelium. A total of 30 palatine tonsillar specimens were obtained from children aged from 3 to 15 years. Histological studies showed moderate vascular changes and more than four apparent epithelial disruptions in the crypt epithelium. FN-ir showed a significant increase in FN in the basal layers of surface epithelium, subepithelial connective tissue and interfollicular areas. Tonsils of children in rheumatic families showed significant increase in FN in subepithelial connective tissue areas with more than one apparent crypt epithelial disruption compared to normal children. We can conclude that FN plays a central role in the RF and differentially distributed in the functional compartments of the palatine tonsil in children with RHD, so FN-ir can be used as a marker for rheumatic susceptibility.

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(1)65 role	(16)4 data	(31)2 alternative	(46)2 indicator
(2)37 for	(17)4 differences	(32)2 aspect	(47)2 mechanism
(3)34 to	(18)3 approach	(33)2 baseline	(48)2 model
(4)28 in	(19)3 causes	(34)2 because	(49)2 molecular
(5)15 implications	(20)3 clinical	(35)2 bivalve,	(50)2 not
(6)11 factor	(21)3 findings	(36)2 complication	(51)2 pathogen
(7)9 null	(22)3 genes	(37)2 components	(52)2 phenomenon
(8)9 and	(23)3 health	(38)2 consequences	(53)2 physiological
(9)8 determinants	(24)3 human	(39)2 contributor	(54)2 protective
(10)8 roles	(25)3 insights	(40)2 coping	(55)2 route
(11)7 factors	(26)3 policy	(41)2 determinant	(56)2 standard
(12)6 cause	(27)3 predictors	(42)2 economic	(57)2 step
(13)5 component	(28)3 public	(43)2 element	(58)2 strategic
(14)5 risk	(29)3 when	(44)2 fish	(59)2 subset
(15)4 as	(30)2 DNA	(45)2 function	(60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---