ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found
304) This can be a challenging differential diagnosis, and the distinctions are important because of differences in management.
--- ABSTRACT ---
PMID:24395190 DOI:10.1002/hon.2129
2015 Hematological oncology
* Practical diagnostic approaches to composite plasma cell neoplasm and low grade B-cell lymphoma/clonal infiltrates in the bone marrow.
- Composite plasma cell neoplasm (PCN) and low grade B-cell lymphoma (B-NHL) in the bone marrow are uncommon and raise the differential diagnosis of B-NHL with plasmacytic differentiation and PCN with lymphoplasmacytic morphology. This can be a challenging differential diagnosis, and the distinctions are important because of differences in management. We report five cases of composite PCN with B-NHL or clonal B-cell infiltrates involving the bone marrow. By using multiple different diagnostic modalities, including immunophenotyping by flow cytometry and immunohistochemistry, cytogenetic analysis and IGH gene rearrangement studies by polymerase chain reaction, we were able to distinguish two distinct clonally unrelated neoplasms in all cases. We describe the utility and pitfalls of these different diagnostic modalities. Flow cytometric analysis with a panel of antibodies that includes CD19, CD56, CD138, CD45 and other aberrant markers commonly expressed by PCN will allow identification of clonally unrelated PCN and B-NHL in a composite neoplasm, and distinguish them from B-NHL with plasmacytic differentiation and PCN with lymphoplasmacytic morphology. Cytogenetic and molecular analyses can give false-negative or false-positive results. In summary, a multimodal approach utilizing these different tools, including clinical data, should be used to arrive at the correct diagnosis.
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(1)65 role (16)4 data (31)2 alternative (46)2 indicator
(2)37 for (17)4 differences (32)2 aspect (47)2 mechanism
(3)34 to (18)3 approach (33)2 baseline (48)2 model
(4)28 in (19)3 causes (34)2 because (49)2 molecular
(5)15 implications (20)3 clinical (35)2 bivalve, (50)2 not
(6)11 factor (21)3 findings (36)2 complication (51)2 pathogen
(7)9 *null* (22)3 genes (37)2 components (52)2 phenomenon
(8)9 and (23)3 health (38)2 consequences (53)2 physiological
(9)8 determinants (24)3 human (39)2 contributor (54)2 protective
(10)8 roles (25)3 insights (40)2 coping (55)2 route
(11)7 factors (26)3 policy (41)2 determinant (56)2 standard
(12)6 cause (27)3 predictors (42)2 economic (57)2 step
(13)5 component (28)3 public (43)2 element (58)2 strategic
(14)5 risk (29)3 when (44)2 fish (59)2 subset
(15)4 as (30)2 DNA (45)2 function (60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---