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448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found

24) Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.

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PMID:24038534 DOI:10.1002/mc.22080

2015 Molecular carcinogenesis

* Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.

- STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo. BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates. There was a concomitant increase in the Lgr-6, Lrig-1, and Sca-1 populations in the Tg mice in contrast to the CD34 and Keratin-15 positive population. In addition, increased expression of c-myc, β-catenin, and epithelial-mesenchymal transition (EMT)-related genes as well as decreased expression of α6-integrin was observed in the hair follicles of Tg mice. Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes. The current data suggest that elevated Stat3 activity leads to depletion of hair follicle KSCs along with a concomitant increase of stem/progenitor cells above the bulge region. Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.

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(1)65 role	(16)4 data	(31)2 alternative	(46)2 indicator
(2)37 for	(17)4 differences	(32)2 aspect	(47)2 mechanism
(3)34 to	(18)3 approach	(33)2 baseline	(48)2 model
(4)28 in	(19)3 causes	(34)2 because	(49)2 molecular
(5)15 implications	(20)3 clinical	(35)2 bivalve,	(50)2 not
(6)11 factor	(21)3 findings	(36)2 complication	(51)2 pathogen
(7)9 null	(22)3 genes	(37)2 components	(52)2 phenomenon
(8)9 and	(23)3 health	(38)2 consequences	(53)2 physiological
(9)8 determinants	(24)3 human	(39)2 contributor	(54)2 protective
(10)8 roles	(25)3 insights	(40)2 coping	(55)2 route
(11)7 factors	(26)3 policy	(41)2 determinant	(56)2 standard
(12)6 cause	(27)3 predictors	(42)2 economic	(57)2 step
(13)5 component	(28)3 public	(43)2 element	(58)2 strategic
(14)5 risk	(29)3 when	(44)2 fish	(59)2 subset
(15)4 as	(30)2 DNA	(45)2 function	(60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---