* Sequence polymorphisms in the D-loop region of mitochondrial DNA and outcome of non-Hodgkin lymphoma.
- Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) might be associated with cancer risk and disease outcome. We have identified 140 SNPs including 26 SNPs with frequency distribution of minor allele greater than 5% in a case-control study for non-Hodgkin lymphoma patients previously. In this study, we assessed the predictive power of D-loop SNPs in NHL patients. Five SNP sites were identified by log-rank test for statistically significant prediction of NHL survival in a univariate analysis. In an overall multivariate analysis, allele 16304 was identified as an independent predictor of NHL outcome. The survival time of NHL patients with 16304C was significantly shorter than that of patients with 16304T (relative risk, 0.513; 95% CI, 0.266-0.989; p = 0.046). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of a poor disease outcome.
=>確認飛行物体;略:IFO
Overview of verb identify
The verb identify has 6 senses (first 6 from tagged texts)
1. (32) identify, place -- (recognize as being; establish the identity of someone or something; "She
identified the man on the 'wanted' poster")
2. (7) name, identify -- (give the name or identifying characteristics of; refer to by name or some
other identifying characteristic property; "Many senators were named in connection with the
scandal"; "The almanac identifies the auspicious months")
3. (6) identify -- (consider (oneself) as similar to somebody else; "He identified with the
refugees")
4. (4) identify -- (conceive of as united or associated; "Sex activity is closely identified with
the hypothalamus")
5. (2) identify, discover, key, key out, distinguish, describe, name -- (identify as in botany or
biology, for example)
6. (2) identify -- (consider to be equal or the same; "He identified his brother as one of the
fugitives")
Overview of adj identified
The adj identified has 1 sense (first 1 from tagged texts)
1. (1) identified -- (having the identity known or established; "the identified bodies were released
for burial")
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