ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [cache]
179) The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.
* Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers.
- The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3 μg/cm2 at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p > 0.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.
=>幹部, おえら方
Overview of adj higher
The adj higher has 2 senses (first 2 from tagged texts)
1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics")
2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning")
Overview of adj high
The adj high has 7 senses (first 5 from tagged texts)
1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a
high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high";
"he has a high opinion of himself")
2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or
upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high
ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high")
3. (10) eminent, high -- (standing above others in quality or position; "people in high places";
"the high priest"; "eminent members of the community")
4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency)
5. (2) high, in high spirits -- (happy and excited and energetic)
6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted)
7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially
marijuana))
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