2015 American journal of Alzheimer's disease and other dementias
* Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.
- Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study.
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Overview of adj higher
The adj higher has 2 senses (first 2 from tagged texts)
1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics")
2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning")
Overview of adj high
The adj high has 7 senses (first 5 from tagged texts)
1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a
high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high";
"he has a high opinion of himself")
2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or
upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high
ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high")
3. (10) eminent, high -- (standing above others in quality or position; "people in high places";
"the high priest"; "eminent members of the community")
4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency)
5. (2) high, in high spirits -- (happy and excited and energetic)
6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted)
7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially
marijuana))
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