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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for high out of >500 occurrences
636281 occurrences (No.11 in the rank) during 5 years in the PubMed. [no cache] 500 found
33) Major depression is a severe psychiatric syndrome with very high prevalence and socio-economic impact.
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PMID:23706576 DOI:10.1016/j.euroneuro.2013.04.013
2015 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
* Developments in the field of antidepressants, where do we go now?
- Major depression is a severe psychiatric syndrome with very high prevalence and socio-economic impact. Its pathophysiology is poorly known, yet several neurotransmitter systems and brain areas have been implicated. Selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) are most used antidepressant treatments. However, these drugs show slow onset of action and limited efficacy, making necessary the use of drug augmentation strategies or more aggressive interventions. Two important observations have emerged in recent years indicating that more rapid and effective antidepressant treatments are possible. Hence, the deep brain stimulation (DBS) of ventral anterior (subgenual) cingulate cortex (Cg25) evokes rapid mood improvements in subgroups of treatment-resistant depressive patients, likely mediated by a functional remodelling of cortico-limbic circuits. On the other hand, the non-competitive NDMA receptor antagonist ketamine can also evoke rapid (e.g., 2h) and persistent (up to 1 wk) improvements in some treatment-resistant patients. Moreover, recent preclinical observations indicate the antidepressant capacity of mGluR agents. Overall, this supports the usefulness of glutamatergic transmission as a new area in antidepressant drug development. On the monoamine side, new preclinical and clinical research should clarify the different roles played by 5-HT receptors in depression as well as the brain areas and circuits responsible for therapeutic improvement. This will lead to the synthesis of new agents blocking the serotonin (and possibly norepinephrine) transporter which will also activate or block 5-HT receptors playing respectively positive (e.g., postsynaptic 5-HT1A, 5-HT4) or negative (e.g., presynaptic 5-HT1A,/1B, 5-HT2A, 5-HT2C,5-HT3, etc.) roles in antidepressant effects.
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(1)18 risk (19)4 gamma (37)2 AT (55)2 importance
(2)14 and (20)4 group (38)2 N/L (56)2 index
(3)12 prevalence (21)4 patient (39)2 PbB (57)2 inter-specific
(4)10 levels (22)4 rate (40)2 accuracy (58)2 internal
(5)9 level (23)4 shear (41)2 age (59)2 job
(6)9 school (24)3 blood (42)2 alcohol (60)2 mass
(7)8 *null* (25)3 concentration (43)2 areas (61)2 population
(8)7 proportion (26)3 density (44)2 birth (62)2 positive
(9)6 in (27)3 dose (45)2 caries (63)2 production
(10)6 lipoprotein (28)3 efficiency (46)2 chemotherapy (64)2 profile
(11)6 liquid (29)3 frequency (47)2 correlation (65)2 relative
(12)6 mortality (30)3 genetic (48)2 dental (66)2 reliability
(13)5 as (31)3 groups (49)2 diet (67)2 resistance
(14)5 autism (32)3 incidence (50)2 exposure (68)2 risks'
(15)5 degree (33)3 patients (51)2 expression (69)2 specificity,
(16)4 concentrations (34)3 rates (52)2 frequencies (70)2 technologies
(17)4 doses (35)3 ulnar (53)2 heart (71)2 tumours
(18)4 for (36)2 ASD (54)2 hydrostatic (72)2 variability

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--- WordNet output for high --- =>1.高いところにある, 高い, 高さが〜の, 高貴な, 高く, 高額の, 興奮状態の, 2.高い所, 高水準 Overview of noun high The noun high has 7 senses (first 1 from tagged texts) 1. (5) high -- (a lofty level or position or degree; "summer temperatures reached an all-time high") 2. high -- (an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high") 3. high -- (a state of sustained elation; "I'm on a permanent high these days") 4. high -- (a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on") 5. high, heights -- (a high place; "they stood on high and observed the countryside"; "he doesn't like heights") 6. senior high school, senior high, high, highschool, high school -- (a public secondary school usually including grades 9 through 12; "he goes to the neighborhood highschool") 7. high gear, high -- (a forward gear with a gear ratio that gives the greatest vehicle velocity for a given engine speed) Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) Overview of adv high The adv high has 4 senses (first 2 from tagged texts) 1. (9) high, high up -- (at a great altitude; "he climbed high on the ladder") 2. (2) high -- (in or to a high position, amount, or degree; "prices have gone up far too high") 3. high, richly, luxuriously -- (in a rich manner; "he lives high") 4. high -- (far up toward the source; "he lives high up the river") --- WordNet end ---