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171) To conclude, PNaAMPS hydrogel is an excellent feeder-free scaffold because of its simplicity, low cost and high efficiency in expanding a large number of miPS cells in vitro.
2015 Journal of tissue engineering and regenerative medicine
* Hydrogels as feeder-free scaffolds for long-term self-renewal of mouse induced pluripotent stem cells.
- Expanding undifferentiated induced pluripotent stem (iPS) cells in vitro is a basic requirement for application of iPS cells in both fundamental research and clinical regeneration. In this study, we intended to establish a simple, low cost and efficient method for the long-term self-renewal of mouse induced pluripotent stem (miPS) cells without using feeder-cells and adhesive proteins. Three scaffolds were selected for the long-term subculture of miPS cells over two months starting from passages 14 to 29: 1) a gelatin coated polystyrene (Gelatin-PS) that is a widely used scaffold for self-renewal of mouse embryonic stem (mES) cells; 2) a neutral hydrogel poly(N,N-dimethylacrylamide) (PDMAAm); and 3) a negatively charged hydrogel poly(2-acrylamido-2-methyl-propane sulfonic acid sodium salt) (PNaAMPS). Each passaged miPS cells on these scaffolds were cryopreserved successfully and the revived cells showed high viability and proliferation. The passaged miPS cells maintained a high undifferentiated state on all three scaffolds and a high level of pluripotency by expressing differentiation markers in vitro and forming teratomas in SCID mice with derivatives of all three germ layers. Compared to Gelatin-PS, the two hydrogels exhibited much better self-renewal performance in terms of high proliferation rate and level of expression of undifferentiated gene markers as well as efficiency in pluripotent teratoma formation. Furthermore, the PNaAMPS hydrogel demonstrated a slightly higher efficiency and simpler operation of cell expansion than the PDMAAm hydrogel. To conclude, PNaAMPS hydrogel is an excellent feeder-free scaffold because of its simplicity, low cost and high efficiency in expanding a large number of miPS cells in vitro.
=>1.高いところにある, 高い, 高さが〜の, 高貴な, 高く, 高額の, 興奮状態の, 2.高い所, 高水準
Overview of noun high
The noun high has 7 senses (first 1 from tagged texts)
1. (5) high -- (a lofty level or position or degree; "summer temperatures reached an all-time high")
2. high -- (an air mass of higher than normal pressure; "the east coast benefits from a Bermuda
high")
3. high -- (a state of sustained elation; "I'm on a permanent high these days")
4. high -- (a state of altered consciousness induced by alcohol or narcotics; "they took drugs to
get a high on")
5. high, heights -- (a high place; "they stood on high and observed the countryside"; "he doesn't
like heights")
6. senior high school, senior high, high, highschool, high school -- (a public secondary school
usually including grades 9 through 12; "he goes to the neighborhood highschool")
7. high gear, high -- (a forward gear with a gear ratio that gives the greatest vehicle velocity for
a given engine speed)
Overview of adj high
The adj high has 7 senses (first 5 from tagged texts)
1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a
high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high";
"he has a high opinion of himself")
2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or
upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high
ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high")
3. (10) eminent, high -- (standing above others in quality or position; "people in high places";
"the high priest"; "eminent members of the community")
4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency)
5. (2) high, in high spirits -- (happy and excited and energetic)
6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted)
7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially
marijuana))
Overview of adv high
The adv high has 4 senses (first 2 from tagged texts)
1. (9) high, high up -- (at a great altitude; "he climbed high on the ladder")
2. (2) high -- (in or to a high position, amount, or degree; "prices have gone up far too high")
3. high, richly, luxuriously -- (in a rich manner; "he lives high")
4. high -- (far up toward the source; "he lives high up the river")
--- WordNet end ---