ELIZA

return kwic search for high out of >500 occurrences
636281 occurrences (No.11 in the rank) during 5 years in the PubMed. [cache]

107) Lung cancer is the leading cause of cancer-related death in both developed and developing countries with unacceptably high mortality even for early-stage cancers.

--- ABSTRACT ---

PMID:23608827 DOI:10.1097/COC.0b013e31828d95d8

2015 American journal of clinical oncology

* Gene expression profiling for early-stage NSCLC.

- Lung cancer is the leading cause of cancer-related death in both developed and developing countries with unacceptably high mortality even for early-stage cancers. Present guidelines do not recommend adjuvant chemotherapy for stage I non-small cell lung carcinoma and prompts a search for a prognostic marker that would separate stage I patients into 2 groups, those who would benefit and those who would not benefit from adjuvant treatment. Studies during the last decade showed that the gene expression profiling can be the biomarker being sought. Many gene expression profiling have been found and reported from the analysis of surgical specimens of resected lung cancers during the last decade, and many of them had been shown to have an excellent predictive accuracy. These profiles used in the studies had not only different gene combinations but also different number of genes and methods of identification. Researchers have used microarray assays, RT-quantitative polymerase chain reaction, and more recently microRNA-based techniques to achieve this goal. Unfortunately, most of the profiles were not sufficiently validated and/or were not used in prospective phase III studies. This review focuses on major studies in the field, future prospects, as well as the lessons learned so far. It is shown that the gene expression profiles have a good chance of being implemented in future everyday practice.

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[frequency of next (right) word to high]

(1)18 risk	(19)4 gamma	(37)2 AT	(55)2 importance
(2)14 and	(20)4 group	(38)2 N/L	(56)2 index
(3)12 prevalence	(21)4 patient	(39)2 PbB	(57)2 inter-specific
(4)10 levels	(22)4 rate	(40)2 accuracy	(58)2 internal
(5)9 level	(23)4 shear	(41)2 age	(59)2 job
(6)9 school	(24)3 blood	(42)2 alcohol	(60)2 mass
(7)8 null	(25)3 concentration	(43)2 areas	(61)2 population
(8)7 proportion	(26)3 density	(44)2 birth	(62)2 positive
(9)6 in	(27)3 dose	(45)2 caries	(63)2 production
(10)6 lipoprotein	(28)3 efficiency	(46)2 chemotherapy	(64)2 profile
(11)6 liquid	(29)3 frequency	(47)2 correlation	(65)2 relative
(12)6 mortality	(30)3 genetic	(48)2 dental	(66)2 reliability
(13)5 as	(31)3 groups	(49)2 diet	(67)2 resistance
(14)5 autism	(32)3 incidence	(50)2 exposure	(68)2 risks'
(15)5 degree	(33)3 patients	(51)2 expression	(69)2 specificity,
(16)4 concentrations	(34)3 rates	(52)2 frequencies	(70)2 technologies
(17)4 doses	(35)3 ulnar	(53)2 heart	(71)2 tumours
(18)4 for	(36)2 ASD	(54)2 hydrostatic	(72)2 variability

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--- WordNet output for high --- =>1.高いところにある, 高い, 高さが〜の, 高貴な, 高く, 高額の, 興奮状態の, 2.高い所, 高水準 Overview of noun high The noun high has 7 senses (first 1 from tagged texts) 1. (5) high -- (a lofty level or position or degree; "summer temperatures reached an all-time high") 2. high -- (an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high") 3. high -- (a state of sustained elation; "I'm on a permanent high these days") 4. high -- (a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on") 5. high, heights -- (a high place; "they stood on high and observed the countryside"; "he doesn't like heights") 6. senior high school, senior high, high, highschool, high school -- (a public secondary school usually including grades 9 through 12; "he goes to the neighborhood highschool") 7. high gear, high -- (a forward gear with a gear ratio that gives the greatest vehicle velocity for a given engine speed) Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) Overview of adv high The adv high has 4 senses (first 2 from tagged texts) 1. (9) high, high up -- (at a great altitude; "he climbed high on the ladder") 2. (2) high -- (in or to a high position, amount, or degree; "prices have gone up far too high") 3. high, richly, luxuriously -- (in a rich manner; "he lives high") 4. high -- (far up toward the source; "he lives high up the river") --- WordNet end ---