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return kwic search for health out of >500 occurrences
353463 occurrences (No.52 in the rank) during 5 years in the PubMed. [no cache] 500 found

337) Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year.

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PMID:23848141 DOI:10.1111/iwj.12125

2015 International wound journal

* Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial.

- Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year. This study sought to evaluate the clinical benefit of topical activated protein C (APC) on chronic lower leg ulcers in patients with diabetes. Twelve patients were randomly assigned to receive either APC (N = 6) or physiological saline (placebo; N = 6) in a randomised, placebo-controlled, double-blind pilot clinical trial. Treatment was administered topically, twice weekly for 6 weeks with final follow-up at 20 weeks. Wound area was significantly reduced to 34·8 ± 16·4% of week 0 levels at 20 weeks in APC-treated wounds (p = 0·01). At 20 weeks, three APC-treated wounds had completely healed, compared to one saline-treated wound. Full-thickness wound edge skin biopsies showed reduced inflammatory cell infiltration and increased vascular proliferation following APC treatment. Patient stress scores were also significantly reduced following APC treatment (p < 0·05), demonstrating improved patient quality of life as assessed by the Cardiff Wound Impact Questionnaire. This pilot trial suggests that APC is a safe topical agent for healing chronic lower leg ulcers in patients with diabetes and provides supporting evidence for a larger clinical trial.

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(1)73 care	(17)5 impact	(33)3 issues	(49)2 cost
(2)35 and	(18)5 impacts	(34)3 literacy	(50)2 data
(3)23 null	(19)5 insurance	(35)3 policy	(51)2 economic
(4)13 promotion	(20)5 problem	(36)3 risk	(52)2 examination
(5)12 Survey	(21)5 system	(37)3 risks	(53)2 factors
(6)12 professionals	(22)4 knowledge	(38)3 services,	(54)2 hazard
(7)8 education	(23)4 providers	(39)3 symptoms	(55)2 is
(8)8 effects	(24)4 surveillance	(40)3 was	(56)2 messages
(9)8 outcomes	(25)3 Insurance	(41)3 workers	(57)2 needs
(10)8 status	(26)3 Promotion	(42)2 Department	(58)2 plan
(11)7 problems	(27)3 as	(43)2 Organization's	(59)2 protection
(12)6 Organization	(28)3 authorities	(44)2 activities	(60)2 sector
(13)6 in	(29)3 centres	(45)2 benefits	(61)2 survey
(14)6 of	(30)3 conditions	(46)2 centers
(15)6 services	(31)3 hazards	(47)2 challenges
(16)5 behaviours	(32)3 interventions	(48)2 concern

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--- WordNet output for health --- =>健康状態, 健康, 調子 Overview of noun health The noun health has 2 senses (first 1 from tagged texts) 1. (21) health, wellness -- (a healthy state of wellbeing free from disease; "physicians should be held responsible for the health of their patients") 2. health -- (the general condition of body and mind; "his delicate health"; "in poor health") --- WordNet end ---