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309169 occurrences (No.70 in the rank) during 5 years in the PubMed. [no cache]
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407) However, AMPK activation can also provide a growth advantage to tumor cells by regulating cellular metabolic plasticity, thus providing tumor cells the flexibility to adapt to metabolic stress.
* The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.
- The AMP-activated protein kinase (AMPK) is a central regulator of cellular metabolism and energy homeostasis in mammalian tissues. Pertinent to cancer biology is the fact that AMPK is situated in the center of a signaling network involving established tumor suppressors including LKB1, TSC2 and p53. However, recent research suggests that AMPK can exert pro- or anti-tumorigenic roles in cancer depending on context. Loss of AMPK activity has been observed in several tumor types, and can cooperate with oncogenic drivers to reprogram tumor cell metabolism and enhance cell growth and proliferation. However, AMPK activation can also provide a growth advantage to tumor cells by regulating cellular metabolic plasticity, thus providing tumor cells the flexibility to adapt to metabolic stress. Here we discuss the contextual nature of the "two faces" of AMPK in cancer, and discuss the rationale and context for employing AMPK activators versus inhibitors for cancer therapy.
=>茂み, 成長, 増加, 発展, 栽培, 腫よう, 成長物
Overview of noun growth
The noun growth has 7 senses (first 5 from tagged texts)
1. (37) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of
an individual organism growing organically; a purely biological unfolding of events involved in an
organism changing gradually from a simple to a more complex level; "he proposed an indicator of
osseous development in children")
2. (20) growth -- (a progression from simpler to more complex forms; "the growth of culture")
3. (3) increase, increment, growth -- (a process of becoming larger or longer or more numerous or
more important; "the increase in unemployment"; "the growth of population")
4. (3) growth -- (vegetation that has grown; "a growth of trees"; "the only growth was some salt
grass")
5. (1) emergence, outgrowth, growth -- (the gradual beginning or coming forth; "figurines presage
the emergence of sculpture in Greece")
6. growth -- ((pathology) an abnormal proliferation of tissue (as in a tumor))
7. growth -- (something grown or growing; "a growth of hair")
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