ELIZA

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385944 occurrences (No.46 in the rank) during 5 years in the PubMed. [no cache] 500 found

383) The experimental animals were divided into a negative pressure group (negative pressure of -125 mmHg applied to the wound for 5 minutes; n = 8), and a negative pressure plus L-NAME group (administration of L-NAME prior to application of the negative pressure; n = 8).

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PMID:23834415 DOI:10.1111/iwj.12121

2015 International wound journal

* Involvement of nitric oxide in the wound bed microcirculatory change during negative pressure wound therapy.

- This study investigated the role of nitric oxide (NO) in the mechanism of blood flow increase in the wound bed during negative pressure wound therapy (NPWT). We developed an improved experimental model that allowed visualisation of the wound bed microcirculation under NPWT. Wounds were created on the mouse ear, taking care to preserve the subdermal vascular plexus, because the wound bed microcirculation was visualised using an intravital microscope system. We investigated whether application of a NO synthase inhibitor (N(G) -nitro-l-arginine methyl ester: L-NAME) might diminish the effect of the NPWT in increasing the wound blood flow. The experimental animals were divided into a negative pressure group (negative pressure of -125 mmHg applied to the wound for 5 minutes; n = 8), and a negative pressure plus L-NAME group (administration of L-NAME prior to application of the negative pressure; n = 8). In the negative pressure group, significant increase of blood flow was observed at 1 minute after the negative pressure application, which was sustained until 5 minutes. On the contrary, in the negative pressure plus L-NAME group, no significant changes were observed throughout the period of observation. These findings suggest that NO synthesis is involved in the wound bed microcirculatory change induced by NPWT.

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(1)49 null	(15)7 received	(29)3 II	(44)2 difference
(2)33 was	(16)5 at	(30)3 after	(45)2 displayed
(3)29 and	(17)5 for	(31)3 comprised	(46)2 dynamics-based
(4)25 of	(18)5 the	(32)3 in	(47)2 exhibited
(5)16 compared	(19)5 to	(33)3 when	(48)2 however,
(6)12 A	(20)4 (p	(34)2 (30	(49)2 improved
(7)12 were	(21)4 B	(35)2 (n	(50)2 included
(8)11 discussions	(22)4 C	(37)2 B,	(51)2 intervention
(9)10 than	(23)4 differences	(38)2 III	(52)2 interventions
(10)9 I	(24)4 or	(39)2 V	(53)2 interviews
(11)8 had	(25)3 1,	(40)2 a	(54)2 patients
(12)8 showed	(26)3 2	(41)2 as	(55)2 presented
(13)8 with	(27)3 4	(42)2 contains	(56)2 that
(14)7 1	(28)3 A,	(43)2 demonstrated

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--- WordNet output for group --- =>一団にする, 集める, 分派, 集団, グループ, 分類する, 演奏家グループ, 集まる, 分ける Overview of noun group The noun group has 3 senses (first 2 from tagged texts) 1. (1345) group, grouping -- (any number of entities (members) considered as a unit) 2. (1) group, radical, chemical group -- ((chemistry) two or more atoms bound together as a single unit and forming part of a molecule) 3. group, mathematical group -- (a set that is closed, associative, has an identity element and every element has an inverse) Overview of verb group The verb group has 2 senses (first 2 from tagged texts) 1. (4) group -- (arrange into a group or groups; "Can you group these shapes together?") 2. (1) group, aggroup -- (form a group or group together) --- WordNet end ---