2015 Journal of tissue engineering and regenerative medicine
* Studies of the humoral factors produced by layered chondrocyte sheets.
- The authors aimed to repair and regenerate articular cartilage with layered chondrocyte sheets, produced using temperature-responsive culture dishes. The purpose of this study was to investigate the humoral factors produced by layered chondrocyte sheets. Articular chondrocytes and synovial cells were harvested during total knee arthroplasty. After co-culture, the samples were divided into three groups: a monolayer, 7 day culture sheet group (group M); a triple-layered, 7 day culture sheet group (group L); and a monolayer culture group with a cell count identical to that of group L (group C). The secretion of collagen type 1 (COL1), collagen type 2 (COL2), matrix metalloproteinase-13 (MMP13), transforming growth factor-β (TGFβ), melanoma inhibitory activity (MIA) and prostaglandin E2 (PGE2) were measured by enzyme-linked immunosorbent assay (ELISA). Layered chondrocyte sheets produced the most humoral factors. PGE2 expression declined over time in group C but was significantly higher in groups M and L. TGFβ expression was low in group C but was significantly higher in groups M and L (p<0.05). Our results suggest that the humoral factors produced by layered chondrocyte sheets may contribute to cartilaginous tissue repair and regeneration.
=>一団にする, 集める, 分派, 集団, グループ, 分類する, 演奏家グループ, 集まる, 分ける
Overview of noun group
The noun group has 3 senses (first 2 from tagged texts)
1. (1345) group, grouping -- (any number of entities (members) considered as a unit)
2. (1) group, radical, chemical group -- ((chemistry) two or more atoms bound together as a single
unit and forming part of a molecule)
3. group, mathematical group -- (a set that is closed, associative, has an identity element and
every element has an inverse)
Overview of verb group
The verb group has 2 senses (first 2 from tagged texts)
1. (4) group -- (arrange into a group or groups; "Can you group these shapes together?")
2. (1) group, aggroup -- (form a group or group together)
--- WordNet end ---