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298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [no cache] 500 found
16) Further studies with larger numbers of patients are required for further evaluation and confirmation of our finding.
--- ABSTRACT ---
PMID:24456074 DOI:10.1111/and.12228
2015 Andrologia
* Human catalase gene polymorphism (CAT C-262T) and risk of male infertility.
- Infertility is the failure of a couple to engender after endeavouring at least one full year of unprotected intercourse. It has been reported that reactive oxygen species contributed to pathogenesis of various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, one of them is catalase which contributes H2 O2 to H2 O and O2 . This study set out to delineate the association of catalase C-262T polymorphism with idiopathic male infertility. The study included 195 men with idiopathic infertility and 190 healthy volunteers. Genomic DNA was extracted from peripheral blood leucocytes. Genotype and allele frequencies were determined in patients and controls using allele-specific PCR (AS-PCR). The prevalence of genotype frequencies of the CAT CC/CT/TT was 31.79%, 65.12% and 3.07%, respectively, in infertile subjects, as against 24.73%, 55.26% and 20%, respectively, in healthy volunteers. Statistical analysis has emerged significant difference from the comparison of either genotype (P < 0.05). Taking into accounts of results, the catalase C-262T polymorphism indicates that CAT-262T/T genotype confers less susceptibility to male infertility. Further studies with larger numbers of patients are required for further evaluation and confirmation of our finding.
--- ABSTRACT END ---
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(1)39 studies (16)4 developed (31)2 analyses (46)2 insights
(2)32 research (17)4 in (32)2 analyzed (47)2 monitoring
(3)18 investigation (18)4 supported (33)2 application (48)2 optimization
(4)18 study (19)3 *null* (34)2 as (49)2 prospective
(5)11 the (20)3 a (35)2 assessed (50)2 protection
(6)10 investigations (21)3 clinical (36)2 complications (51)2 spread
(7)8 analysis (22)3 evaluation (37)2 divided (52)2 suggests
(8)7 evidence (23)3 exploration (38)2 elucidate (53)2 supporting
(9)7 phylogenetic (24)3 explore (39)2 enhance (54)2 supports
(10)6 explored (25)3 for (40)2 episodes (55)2 taxonomic
(11)5 development (26)3 increased (41)2 evaluated (56)2 that
(12)5 support (27)3 investigate (42)2 examination (57)2 used
(13)5 validation (28)3 molecular (43)2 identification
(14)4 by (29)3 understand (44)2 improvement
(15)4 confirmed (30)2 advances (45)2 increase

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--- WordNet output for further --- =>1.さらにずっと, さらに先に, 一層遠く, その上, 更に, もっと遠い, なお一層の, さらに遠く, もっと先に, いっそうはるかに, さらにまた, さらになお(furthermore), 2.進める, 助成する, 促進する Overview of verb further The verb further has 2 senses (first 2 from tagged texts) 1. (7) foster, further -- (promote the growth of; "Foster our children's well-being and education") 2. (2) promote, advance, boost, further, encourage -- (contribute to the progress or growth of; "I am promoting the use of computers in the classroom") Overview of adj further The adj further has 1 sense (first 1 from tagged texts) 1. (2) further, farther -- (more distant in especially degree; "nothing could be further from the truth"; "further from our expectations"; "farther from the truth"; "farther from our expectations") Overview of adv further The adv further has 3 senses (first 3 from tagged texts) 1. (33) further, farther -- (to or at a greater extent or degree or a more advanced stage (`further' is used more often than `farther' in this abstract sense); "further complicated by uncertainty about the future"; "let's not discuss it further"; "nothing could be further from the truth"; "they are further along in their research than we expected"; "the application of the law was extended farther"; "he is going no farther in his studies") 2. (10) further -- (in addition or furthermore; "if we further suppose"; "stated further that he would not cooperate with them"; "they are definitely coming; further, they should be here already") 3. (1) farther, further -- (to or at a greater distance in time or space (`farther' is used more frequently than `further' in this physical sense); "farther north"; "moved farther away"; "farther down the corridor"; "the practice may go back still farther to the Druids"; "went only three miles further"; "further in the future") Overview of adv far The adv far has 5 senses (first 4 from tagged texts) 1. (61) far -- (to a considerable degree; very much; "a far far better thing that I do"; "felt far worse than yesterday"; "eyes far too close together") 2. (39) far -- (at or to or from a great distance in space; "he traveled far"; "strayed far from home"; "sat far away from each other") 3. (22) far -- (at or to a certain point or degree; "I can only go so far before I have to give up"; "how far can we get with this kind of argument?") 4. (3) far -- (remote in time; "if we could see far into the future"; "all that happened far in the past") 5. far -- (to an advanced stage or point; "a young man who will go very far") --- WordNet end ---