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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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297) The review is organised with a comparative focus on the functional domains of motor control, cognition and behavioural disturbance (akin to psychiatric disturbance in people) and how our knowledge of the underlying physiological changes that are manifest in the HD mouse lines correspond to those seen in the HD clinical population.
- In this review, we explore the similarities and differences in the behavioural neurobiology found in the mouse models of Huntington's disease (HD) and the human disease state. The review is organised with a comparative focus on the functional domains of motor control, cognition and behavioural disturbance (akin to psychiatric disturbance in people) and how our knowledge of the underlying physiological changes that are manifest in the HD mouse lines correspond to those seen in the HD clinical population. The review is framed in terms of functional circuitry and neurotransmitter systems and how abnormalities in these systems impact on the behavioural readouts across the mouse lines and how these may correspond to the deficits observed in people. In addition, interpretational issues associated with the data from animal studies are discussed.
=>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な
Overview of adj functional
The adj functional has 6 senses (first 2 from tagged texts)
1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing
in which every word is functional"; "functional architecture")
2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness")
3. functional -- (relating to or based on function especially as opposed to structure; "the problem
now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather
than a geographical basis")
4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the
toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still
usable"; "an operational aircraft"; "the dishwasher is now in working order")
5. functional -- (designed for or adapted to a function or use; "functional education selects
knowledge that is concrete and usable rather than abstract and theoretical"; "functional
architecture")
6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of
performing; "in running (or working) order"; "a functional set of brakes")
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