* H(N), N(H), C (α), C (β), and methyl group assignments of filamin multidomain fragments IgFLNc4-5 and IgFLNa3-5.
- Filamins regulate the actin cytoskeleton by cross-linking actin filaments, linking the cytoskeleton to the cell membrane, and through interaction with numerous binding partners such as intracellular signalling molecules, ion channels, receptors, enzymes and transcription factors. The rod region of filamins consists of 24 immunoglubulin (Ig)-like repeats, for some of which the functional unit is a domain pair. Our aim is to study filamin Ig domain-domain interactions and quaternary arrangement as well as to locate peptide binding sites on domain assemblies. We report here the H(N), N(H), C(α), C(β), and methyl group assignments of filamin A three-domain fragment IgFLNa3-5 and filamin C two-domain fragment IgFLNc4-5.
=>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な
Overview of adj functional
The adj functional has 6 senses (first 2 from tagged texts)
1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing
in which every word is functional"; "functional architecture")
2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness")
3. functional -- (relating to or based on function especially as opposed to structure; "the problem
now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather
than a geographical basis")
4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the
toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still
usable"; "an operational aircraft"; "the dishwasher is now in working order")
5. functional -- (designed for or adapted to a function or use; "functional education selects
knowledge that is concrete and usable rather than abstract and theoretical"; "functional
architecture")
6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of
performing; "in running (or working) order"; "a functional set of brakes")
--- WordNet end ---