ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
143) This computational study integrates anatomical and physiological data to assess the functional role of the lateral excitatory connections between layer 2/3 (L2/3) pyramidal cells (PCs) in shaping their response during early stages of intracortical processing of a whisker deflection (WD).
--- ABSTRACT ---
PMID:24165834 DOI:10.1093/cercor/bht268
2015 Cerebral cortex (New York, N.Y. : 1991)
* Contribution of intracolumnar layer 2/3-to-layer 2/3 excitatory connections in shaping the response to whisker deflection in rat barrel cortex.
- This computational study integrates anatomical and physiological data to assess the functional role of the lateral excitatory connections between layer 2/3 (L2/3) pyramidal cells (PCs) in shaping their response during early stages of intracortical processing of a whisker deflection (WD). Based on in vivo and in vitro recordings, and 3D reconstructions of connected pairs of L2/3 PCs, our model predicts that: 1) AMPAR and NMDAR conductances/synapse are 0.52 ± 0.24 and 0.40 ± 0.34 nS, respectively; 2) following WD, connection between L2/3 PCs induces a composite EPSPs of 7.6 ± 1.7 mV, well below the threshold for action potential (AP) initiation; 3) together with the excitatory feedforward L4-to-L2/3 connection, WD evoked a composite EPSP of 16.3 ± 3.5 mV and a probability of 0.01 to generate an AP. When considering the variability in L4 spiny neurons responsiveness, it increased to 17.8 ± 11.2 mV; this 3-fold increase in the SD yielded AP probability of 0.35; 4) the interaction between L4-to-L2/3 and L2/3-to-L2/3 inputs is highly nonlinear; 5) L2/3 dendritic morphology significantly affects L2/3 PCs responsiveness. We conclude that early stages of intracortical signaling of WD are dominated by a combination of feedforward L4-L2/3 and L2/3-L2/3 lateral connections.
--- ABSTRACT END ---
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[frequency of next (right) word to functional]
(1)50 magnetic (18)4 gastrointestinal (35)3 integration (52)2 connections
(2)38 connectivity (19)4 outcome (36)3 interactions (53)2 differentiation
(3)29 and (20)4 outcomes (37)3 movement (54)2 domains
(4)8 limitations (21)4 relationships (38)3 single (55)2 endurance
(5)7 network (22)4 unit (39)3 status (56)2 health
(6)7 recovery (23)3 Assessment (40)3 status, (57)2 imaging
(7)7 role (24)3 MRI (41)3 studies (58)2 impact
(8)6 changes (25)3 Well-Being (42)2 CD133 (59)2 integrity
(9)6 results (26)3 activation (43)2 HL (60)2 losses
(10)5 alterations (27)3 brain (44)2 ability (61)2 networks
(11)5 limitation (28)3 consequences (45)2 activity (62)2 neuronal
(12)5 neuroimaging (29)3 coupling (46)2 analyses (63)2 organization
(13)5 properties (30)3 decline (47)2 as (64)2 parameters
(14)5 theory (31)3 deficits (48)2 assays (65)2 roles
(15)4 capacity (32)3 differences (49)2 assessment (66)2 significance
(16)4 connectivity, (33)3 impairment (50)2 characteristics (67)2 specialization
(17)4 foods (34)3 improvement (51)2 cognitive

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--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---